ID A0A3N4J3K8_9PEZI Unreviewed; 548 AA.
AC A0A3N4J3K8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 22-FEB-2023, entry version 11.
DE RecName: Full=Telomere-length maintenance and DNA damage repair domain-containing protein {ECO:0000259|SMART:SM01342};
DE Flags: Fragment;
GN ORFNames=L873DRAFT_1708634 {ECO:0000313|EMBL:RPA92726.1};
OS Choiromyces venosus 120613-1.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC Pezizales; Tuberaceae; Choiromyces.
OX NCBI_TaxID=1336337 {ECO:0000313|EMBL:RPA92726.1, ECO:0000313|Proteomes:UP000276215};
RN [1] {ECO:0000313|EMBL:RPA92726.1, ECO:0000313|Proteomes:UP000276215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=120613-1 {ECO:0000313|EMBL:RPA92726.1,
RC ECO:0000313|Proteomes:UP000276215};
RX PubMed=30420746; DOI=10.1038/s41559-018-0710-4;
RA Murat C., Payen T., Noel B., Kuo A., Morin E., Chen J., Kohler A.,
RA Krizsan K., Balestrini R., Da Silva C., Montanini B., Hainaut M.,
RA Levati E., Barry K.W., Belfiori B., Cichocki N., Clum A., Dockter R.B.,
RA Fauchery L., Guy J., Iotti M., Le Tacon F., Lindquist E.A., Lipzen A.,
RA Malagnac F., Mello A., Molinier V., Miyauchi S., Poulain J., Riccioni C.,
RA Rubini A., Sitrit Y., Splivallo R., Traeger S., Wang M., Zifcakova L.,
RA Wipf D., Zambonelli A., Paolocci F., Nowrousian M., Ottonello S.,
RA Baldrian P., Spatafora J.W., Henrissat B., Nagy L.G., Aury J.M.,
RA Wincker P., Grigoriev I.V., Bonfante P., Martin F.M.;
RT "Pezizomycetes genomes reveal the molecular basis of ectomycorrhizal
RT truffle lifestyle.";
RL Nat. Ecol. Evol. 2:1956-1965(2018).
CC -!- FUNCTION: Serine/threonine protein kinase which activates checkpoint
CC signaling upon genotoxic stresses such as ionizing radiation (IR),
CC ultraviolet light (UV), or DNA replication stalling, thereby acting as
CC a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-
CC Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of
CC DNA damage, involved in the regulation of DNA damage response
CC mechanism. Required for the control of telomere length and genome
CC stability. {ECO:0000256|ARBA:ARBA00025079}.
CC -!- SUBUNIT: Associates with DNA double-strand breaks.
CC {ECO:0000256|ARBA:ARBA00011370}.
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DR EMBL; ML120466; RPA92726.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3N4J3K8; -.
DR STRING; 1336337.A0A3N4J3K8; -.
DR Proteomes; UP000276215; Unassembled WGS sequence.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021668; TAN.
DR Pfam; PF11640; TAN; 1.
DR SMART; SM01342; TAN; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000276215}.
FT DOMAIN 1..112
FT /note="Telomere-length maintenance and DNA damage repair"
FT /evidence="ECO:0000259|SMART:SM01342"
FT REGION 135..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:RPA92726.1"
SQ SEQUENCE 548 AA; 61359 MW; 7EA5DD6111392390 CRC64;
LNDKGYHKMF EAIFRAVVKE KLIYARQNKP SLVKSVGSRL SLCASVFRLA VEQGVLHIRN
KTFKALSKHI IDILPQGDGL CEPISLDYIK ALRTCLAYSP HAEHIDKKEW ATLARFCCTH
VESQLGLLIG DPESADEDAS GSRNIRLSLS RETSSTSRRS QPPSQGIPRL NHDSEELMLC
LEILLKTPDA PIVDHDEMVI RTILGFLISQ PTVTRAHPPA FTALNSVLGV IATNNISLTA
KVAQGIVPVL TKLWDSKQPT FREQMMITLI YILPQIHTII GEGRSRTLRR KVEALSEALF
VECSGRADRD QLQLDDLVFP SPLKTFDAEI TPLGLQAFCL RKGNQKAEMN WIVPQLMATV
VNLLDKSGEN RVGSNGKAPE EDRNKRLKVS KNFEELMRNA RSMITSRKLC ALQTLPFLVH
QRDMESEDCA FSKSASDPSH RPVWNQIWQL CARYSANQAT CRAACHLMRI ILAVDLVPYT
EISKEVDAVI LSIDLSGPAN VVDSSLAVWC LILEKRNTVA HSSILQPGER LLQWLISKWR
PGMLSFFV
//
