ID A0A3N4KPW8_9PEZI Unreviewed; 3789 AA.
AC A0A3N4KPW8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Non-specific serine/threonine protein kinase {ECO:0008006|Google:ProtNLM};
GN ORFNames=P167DRAFT_506485 {ECO:0000313|EMBL:RPB12496.1};
OS Morchella conica CCBAS932.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC Pezizales; Morchellaceae; Morchella.
OX NCBI_TaxID=1392247 {ECO:0000313|EMBL:RPB12496.1, ECO:0000313|Proteomes:UP000277580};
RN [1] {ECO:0000313|EMBL:RPB12496.1, ECO:0000313|Proteomes:UP000277580}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCBAS932 {ECO:0000313|EMBL:RPB12496.1,
RC ECO:0000313|Proteomes:UP000277580};
RX PubMed=30420746; DOI=10.1038/s41559-018-0710-4;
RA Murat C., Payen T., Noel B., Kuo A., Morin E., Chen J., Kohler A.,
RA Krizsan K., Balestrini R., Da Silva C., Montanini B., Hainaut M.,
RA Levati E., Barry K.W., Belfiori B., Cichocki N., Clum A., Dockter R.B.,
RA Fauchery L., Guy J., Iotti M., Le Tacon F., Lindquist E.A., Lipzen A.,
RA Malagnac F., Mello A., Molinier V., Miyauchi S., Poulain J., Riccioni C.,
RA Rubini A., Sitrit Y., Splivallo R., Traeger S., Wang M., Zifcakova L.,
RA Wipf D., Zambonelli A., Paolocci F., Nowrousian M., Ottonello S.,
RA Baldrian P., Spatafora J.W., Henrissat B., Nagy L.G., Aury J.M.,
RA Wincker P., Grigoriev I.V., Bonfante P., Martin F.M.;
RT "Pezizomycetes genomes reveal the molecular basis of ectomycorrhizal
RT truffle lifestyle.";
RL Nat. Ecol. Evol. 2:1956-1965(2018).
CC -!- FUNCTION: Serine/threonine protein kinase which activates checkpoint
CC signaling upon genotoxic stresses such as ionizing radiation (IR),
CC ultraviolet light (UV), or DNA replication stalling, thereby acting as
CC a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-
CC Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of
CC DNA damage, involved in the regulation of DNA damage response
CC mechanism. Required for the control of telomere length and genome
CC stability. {ECO:0000256|ARBA:ARBA00025079}.
CC -!- SUBUNIT: Associates with DNA double-strand breaks.
CC {ECO:0000256|ARBA:ARBA00011370}.
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DR EMBL; ML119128; RPB12496.1; -; Genomic_DNA.
DR STRING; 1392247.A0A3N4KPW8; -.
DR InParanoid; A0A3N4KPW8; -.
DR Proteomes; UP000277580; Unassembled WGS sequence.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000277580}.
FT DOMAIN 2616..3174
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3435..3760
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3757..3789
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 162..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2013..2045
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3189..3258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2015..2045
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3193..3254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3789 AA; 430478 MW; DD13E2EF1CD80C5E CRC64;
MAGGTPHADV YAARLGDSTL DVKLKLQIAG ELRDSIDVFT HVPTEYTKFL QKLMPVFFTI
LNGQPVFIST SPDQKLRNII LDTIHRFPFS PIEALEPYAV DLMTLLMNLV KTENEDNAVL
CMKTIIDFQR NYQKQLTEKV QPFLDLIQEM FYMMPKAVKE TFDNPSSTTG GTPGMPGTPG
NTGQNFQSPR PMSPMNAGQD PGADPQQPTK MLVKGMQSFK VLAECPIIVV SLFQAHRSCV
HKNVKLFVPL IQDMLQLQAG PQEEAHKHAK AKGEVFTGVS PAIKNRVAFG EFITAQVKTM
SFLAYVLRVY AQQLQDFLPK LPEIVVRLLK DCPRERSGAR KELLVATRHI INFNFRKIFL
NKIDELLDER VLIGDGLTVY ETMRPLAYSM LADLIHHVRD SLGREQIGRT VEVYTKNLHD
NFPGTSFQTM SAKLLLNLAE FIAKLEDKQE ARHFLIMILD AIAEKFKAMN RQYENAVKQS
RLNALTKEEG NSEEPSTDLA APAKREEYDE IDIFLATPIK TSNPKERGAD PVSDNKFLFK
NLMNGLKSML FALRSCNPPA KNNENNPQNW NEVAYGFSAE EVNIIIKLFR EGARVFKYYG
VEYESKPSDP NTSPVEFLTN HFMVPSGKEE KELLETFATV FHCIDPATFH EVFHSEIPHL
YEMMFEHTAL LHVPQFFLAS EATSPSFCGM LLQFLMDHIE EVGTSDTRKS QILLRLFKLS
FMAVTLFSNQ NEQVLLPHVS KIVLKSISLS TTAEEPMNYF LLLRSLFRSI GGGRFEHLYK
EILPLLEVLL EVLNTLLISA RNIVQRDLYV ELCLTVPARL SNLLPHLSFL MKPLVVALRA
GHELVSQGLR TLELCVDNLT ADYLDPIMAP VIDDLMAALW DHLKPLPYSH VHSHTTMRIL
GKLGGRNRRF LTHPPPLPFK LYADDACSVN IRLHGAPGER AFPILSAVDL AIERLFDMKP
PKSDQDKATD TFYKHQSLRL LSANLKLFIG YDQLPEDFAQ LVRIQANDLA AGSTDLAAAV
IVPSDRNKPV FKKHDQEATL RKLLRSIIHA VSIPQLEEEA MALTYDVCRH FTILELGKSV
TEMRQKTQQF MVNSGEGPMH LDSRVLADAI ADCLSSEHAA VRETAKKAMK VIYDTAATLF
GSNEMVHKLP FFQWLAKTFC HSCYEEEWYP KSGGCLGIRA LTEDLDMGEA WMVERQHDFV
RALLYVIKDM PPDLPASTRE CAQSTLDLVL RKCNQNVSRE EIGTYHSKSF NLCALLICEI
SNPNKHVRET AQASFTTLSN ILGVGIHALM TPVKERLLTP IFNKPLRALP FASQIGYIDA
ITFCLSLQPA FLEFNEEMNR LMMEALALAD ADDDALSNNR IPEHRTTESV LNLRVVCIKL
LSTAITYQDF AQPDKSHTRG RIIAVFFKSL YSKSHEVIEA ANSGLKGVLA QTNKLPKDLL
QNGLRPILMN LSDPKRLNVA GLEGLARLLE LLTNYFKVEI GSRLLDHLKN LAEPNVLQQT
SFKLLEQNPN IRVIASILNI FHLLPPAAVQ FLEEMFKIVI DLEEKLRRTQ HSPFRAPLLK
FVNRYPAETW GFIKPKMTDL RYGRIFSQLL ADESSEAMRN VVSSDTTGLL GATINIEGKT
EEERFVAQVN AVNIVYSIAR HPSSAEWLVK NRDLMERLLR AGVEIREKLK EGKVPVPIRL
GVDQSSETLQ EIFMLYLTHA EQDLEFLFHV IDARTSNKLK RSNALTHYIY TKIICAGSIE
HWRNVIHRCL DLYTTKASTQ DTKTFAFRHL VNPILAMDVQ RGSLPVNGQK LVDRNMIEAI
HAKIWRPNLG DIGDDASPGL DHSRMELLQM SALLIKDHNS ILAEARKDVI KFGWNYIKLE
DIVNKQAAYV LIAFFIKHYD TPSKIVIQIY VALLKAHQHE GRALVTQALE LIAPVLKKRV
PNVSDPRYPI WARWPRRILS EEGHNQQQMT NIFQFLVKHG DLFYESREHF LSWIVTSLPK
LVLHLPNPST ENKKLSINLM ILIRDWEKRR FTEMQSQSPD ASPSRKRKLQ QPPSDSRSPS
IGGSQGMAGN TEYAVAQPLR ILVIKHLVTF ICSLNEKFST SDLCRKALGL LADFLGPEYW
GDLEIELFPK IMDQHLVTND ITEAQHLPGF LNALQVLRVI LDLKSDEWVM QRLPELQRIL
EKSLRSDLPE VQESLQPVLA RVLQAIPAEK EEGEEEEEDV KDSPATVFTT LLTTIVQENL
NTNLMSSVHI LWTLSQKRPA VIDDHIAALM KAFQKIGKDH LSSTAATPGQ SLVVNLPNSV
KPEPNAGGNS QVFDAETTTK LLRMVIDVAA SRVSVLGDQR RPFLSVMAQL VEKSSSTELC
TKILGIVRDW VFGSTESFPT LKEKTAVLSK MLSFETRPDP ILCSKFLDLV IDIYESPAVN
NTELTVRLEH AFLVGTRAKD VNMRNRFLQI FDRSLSRTIS SRISFVLGTQ NWETLADSYW
LNQATHLLFG SVDMDTRVEL HSEDLRIATA SSIFSTYNAD SRKDSLMLDD KFEDLMYRHR
KFCQSLAEVK AGDIFQPIAQ LQHLDASVAH QIWIALFPLC WSALGKEDRQ DLSRGIVGLL
AKEWHQRQMD KRPNVIQSLL EGCEIAKPKF TLPPHMVKFL SKTYDAWYTA LHMLEDSANV
PPMDSPIVRE SNCDALAEMY SAIQEEDLFY GLWRRRAEYL ETNAAVSFEQ NGMWDKAQQM
YENAQIKART GALPFSNSEY MLWEDHWVLC AQKLQQWEIL SEFAKHENYN DLLLECGWRL
LENWNGIDGE RMDQTIKSLM DAPTPRRFFF AAFMALQKVH QKTEVPAEFS RLCDEAIQLS
LRKWHNLPRR ITNAHIPLLQ AFQQLVELHD ASVIYSSLST TNAQNLDAKS QELKLLLGTW
RDRLPNVWDD INSWHDLVTW RQHIFHSINN TYLPLLPVQA QSAGGNSSNN SYAYRGYHET
AWIINRFAHV ARKHQLPEVC ISQLSKIYTL PNIEIQEAFL KLREQAKCHY QNPLELTQGL
EVINNTNLGY FGAQQKAEFY TLKGMFLSKL KQKEEANEAF GLALYHDLKL PKAWAEWGYY
NDSLFKETPG EMQPAGNAVS CYLEAAGLYK SGKARKLLGR VLWLLSLDDA SATISSAFDA
YKGDTPVWYW ITYIPQLLTS LSHKEARLAR GILIKIAKSY PQALYFLLRT SREDYQVIKK
QTAAAAASNR GKAGSPIVTQ ATPLVRQGSV PNGTDAGRAS SPQGNQNVQT QTNSAGSPIV
PNGPSVSSPA AAVPSPQPQV KRLPWEYAEE IMSVLKTAFP LLALSMETMG DQIQKFFKCP
PDEDAYRLIV ALLNDGLQWI ARINPSLDDS KLPPSTESNI TRFAETILPA NIRVAFEADF
VNVKPNLFAY IERLRKWRDR FEEKLDRRPP YQNLENYSPH LSEFRFQKFD DVEVPGQYLL
HKDNNKDFVR IDRFLPRVDV VRGYGVCHRR LKLRGHDGSV HAFAIQHPAA RHCRREERIL
QLFRIFNGVL SRRKESRRRN LGFHLPLMVP LAPHIRIVQD DSSYISLQGI YEDHCRRTGM
SKDDPLIFSL KKVIASLDPS KPATQLVSPN IKLEIFNAIQ KEMVPQDVAL EFLSKSYPSF
TEFFLFRRQF CYQYAALTFM TYIMSMSNRF PHKMFIARET GNIWGSELIP AMASTNAFFH
NNETVPFRFT PNIQTLMGPI AIEGIFSCAV MAIARCLTEP EFELEQHLSV FVRDEMIFWF
TQQHRSGLGE QQLREKVQMN SEIICRRATS LAQAGQGNLP ANQTVIDLIN KAANPINLAQ
LDNLWMPYL
//
