ID A0A3N4LW97_9PEZI Unreviewed; 919 AA.
AC A0A3N4LW97;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=DNA mismatch repair protein {ECO:0000313|EMBL:RPB25452.1};
GN ORFNames=L211DRAFT_82021 {ECO:0000313|EMBL:RPB25452.1};
OS Terfezia boudieri ATCC MYA-4762.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC Pezizales; Pezizaceae; Terfezia.
OX NCBI_TaxID=1051890 {ECO:0000313|EMBL:RPB25452.1, ECO:0000313|Proteomes:UP000267821};
RN [1] {ECO:0000313|EMBL:RPB25452.1, ECO:0000313|Proteomes:UP000267821}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4762 {ECO:0000313|EMBL:RPB25452.1,
RC ECO:0000313|Proteomes:UP000267821};
RX PubMed=30420746; DOI=10.1038/s41559-018-0710-4;
RA Murat C., Payen T., Noel B., Kuo A., Morin E., Chen J., Kohler A.,
RA Krizsan K., Balestrini R., Da Silva C., Montanini B., Hainaut M.,
RA Levati E., Barry K.W., Belfiori B., Cichocki N., Clum A., Dockter R.B.,
RA Fauchery L., Guy J., Iotti M., Le Tacon F., Lindquist E.A., Lipzen A.,
RA Malagnac F., Mello A., Molinier V., Miyauchi S., Poulain J., Riccioni C.,
RA Rubini A., Sitrit Y., Splivallo R., Traeger S., Wang M., Zifcakova L.,
RA Wipf D., Zambonelli A., Paolocci F., Nowrousian M., Ottonello S.,
RA Baldrian P., Spatafora J.W., Henrissat B., Nagy L.G., Aury J.M.,
RA Wincker P., Grigoriev I.V., Bonfante P., Martin F.M.;
RT "Pezizomycetes genomes reveal the molecular basis of ectomycorrhizal
RT truffle lifestyle.";
RL Nat. Ecol. Evol. 2:1956-1965(2018).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
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DR EMBL; ML121537; RPB25452.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3N4LW97; -.
DR STRING; 1051890.A0A3N4LW97; -.
DR InParanoid; A0A3N4LW97; -.
DR Proteomes; UP000267821; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03285; ABC_MSH2_euk; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR032642; Msh2_ATP-bd.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000267821}.
FT DOMAIN 727..743
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
SQ SEQUENCE 919 AA; 103283 MW; 11676B9A56FBB933 CRC64;
MTSRPELKVD DESGFIASFN KLPETDAIRI FERSDFYTVH GQDALFVAQT VYKTTSVIRQ
LGSGKNSLAS CTLSIAAFRN FLREVLFRQG KRIEIWASAR GTKNGWELVK QASPGNLQDI
EEDLAGQIDS SPVILALKVS TKGDQRVVGV AFADASVREL GVSEFVDNDL YSNLESLLIQ
LGVRECIIQD DPQKKDFELG KVKGVVDRVG ISTTFKKSGE FAIKDIEQDL SRLLASEKAG
VLPQTELKLA MGAASALIRY LGLMSDDTNF GQYQLYQHDL AQYMKLDASA LKALNLMPGP
RDGAKNMSLY GLLNKCKTSI GTRLLGQWLK QPLMDLEEIE KRHILVEAFV EDTALRQTMQ
EEHLKSIPDL YRLAKRFQRK LATLEDVVRA YQVVIRLPGI IETLEGVMDE KYRDLLDAQY
TNNLREYSSN FTNLQELVET TVDLDALDNH EFKIKPEFHE DLRNISSRID ELKSKMDVEH
KRAARDLGVE IDKKLFLEDH RVHGWCFRLT RTEAGVIRNN RDYREISTQK NGVYFTTDRL
STLRREYDQQ TQNYNSTQSG LVNEVVAVAA SFTPVLEQVA EVVGHLDVIV SFAHVSVHAP
SPYVRPTMHP RGQGNTILKE ARHPCMEVQD DIQFITNDVN LSRGESEFLI ITGPNMGGKS
TYIRQIGVIA LMAQAGCFVP CSEAELTIFD CILARVGASD SQLKGVSTFM AEMLETATIL
KSATSDSLII IDELGRGTST YDGFGLAWAI SEFIVKEIRC FTMFATHFHE LTALVDSHPQ
VQNLHVVAHI SDEKDKHREV TLLYKVEKGV CDQSFGIHVA ELVRFPPKVI NMAKRKADEL
EDFTAKHDDE ASKVSKEDVA EGSIVLKKLL VEWKDMVKQS EQKGKKMSKE EMREALRGLV
EGKYAGEMDK PFLKSVLAL
//
