ID   A0A3N4N7Y9_9FLAO        Unreviewed;       585 AA.
AC   A0A3N4N7Y9;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 13.
DE   SubName: Full=Aromatic amino acid hydroxylase {ECO:0000313|EMBL:RPD91218.1};
GN   ORFNames=EGM88_14875 {ECO:0000313|EMBL:RPD91218.1};
OS   Aureibaculum marinum.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Aureibaculum.
OX   NCBI_TaxID=2487930 {ECO:0000313|EMBL:RPD91218.1, ECO:0000313|Proteomes:UP000270856};
RN   [1] {ECO:0000313|EMBL:RPD91218.1, ECO:0000313|Proteomes:UP000270856}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BH-SD17 {ECO:0000313|EMBL:RPD91218.1,
RC   ECO:0000313|Proteomes:UP000270856};
RA   Ji X.;
RT   "Aureibaculum marinum gen. nov., sp. nov., a member of the family
RT   Flavobacteriaceae isolated from the Bohai Sea.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|ARBA:ARBA00001954,
CC         ECO:0000256|PIRSR:PIRSR601273-2};
CC   -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC       hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RPD91218.1}.
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DR   EMBL; RPFJ01000074; RPD91218.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3N4N7Y9; -.
DR   OrthoDB; 9780502at2; -.
DR   Proteomes; UP000270856; Unassembled WGS sequence.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016714; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR   GO; GO:0009072; P:aromatic amino acid metabolic process; IEA:InterPro.
DR   CDD; cd00361; arom_aa_hydroxylase; 1.
DR   Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1.
DR   InterPro; IPR001273; ArAA_hydroxylase.
DR   InterPro; IPR036951; ArAA_hydroxylase_sf.
DR   InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR   InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR   PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR   PANTHER; PTHR11473:SF24; PHENYLALANINE-4-HYDROXYLASE; 1.
DR   Pfam; PF00351; Biopterin_H; 2.
DR   SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR   PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR601273-2};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR601273-2};
KW   Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000270856}.
FT   DOMAIN          1..340
FT                   /note="Biopterin-dependent aromatic amino acid hydroxylase
FT                   family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51410"
FT   BINDING         129
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT   BINDING         134
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT   BINDING         219
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
SQ   SEQUENCE   585 AA;  66094 MW;  47AFA710E01C68FC CRC64;
     MNFKSNKIIA RLPKHLQAFV IRQPYNEYTY QNQAVWRYVM RKNIDYLAKV AHKSYIPGLA
     KAGISVNTIP RMQGMNRILK ELGWAAVSVD GFIPPNAFME FQAYNTLVIA ADIRTINHIE
     YTPAPDIIHE AAGHAPIIAN PEYAEYLRRF GEIGSKAISS SKDYELYEAI RHLSIIKENP
     NTDKNEIIKA DKRVAEVAKS MTELSEMAKI RNLHWWTVEY GLIGTVENPK IYGAGLLSSI
     GESQWCMSKK VKKVPYSIEA ADTDFDITKP QPQLFVTPDF AHLSLVLEEY ANKMALRNGG
     LKGIKKLIDS KNLGTIELST GIQISGNFNE VIADENENPV YVKTIDKTAL AYKNKELIGH
     GITQHADGFG SPIGKLKGIN IAIEDMSPTD LEAYGIYEGK VVHLKFEGQI SVSGEIITGK
     RNLQGKIILI SFKNCTVKHK ENLLFHPDWG IYDMAVGKEV ISAYSGVADA ENFGLSFEPP
     KEKTQKISYT EKDKKLHDLY GEVRKIREKG KLNYIRLEEI FIILKLEFPN EWLLPLEIVE
     LVYKENTQFK KNIINYLETL AGNKSIAHLI KDGLTLLEKD MKKIL
//