ID   A0A3N4RF87_9ACTN        Unreviewed;       347 AA.
AC   A0A3N4RF87; A0A8G1X9Z5;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Threonine dehydrogenase-like Zn-dependent dehydrogenase {ECO:0000313|EMBL:RPE32002.1};
GN   ORFNames=EDD38_0247 {ECO:0000313|EMBL:RPE32002.1}, EDD39_6460
GN   {ECO:0000313|EMBL:ROR38280.1};
OS   Kitasatospora cineracea.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Kitasatospora.
OX   NCBI_TaxID=88074 {ECO:0000313|EMBL:RPE32002.1, ECO:0000313|Proteomes:UP000266906};
RN   [1] {ECO:0000313|Proteomes:UP000266906, ECO:0000313|Proteomes:UP000267408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44780 {ECO:0000313|EMBL:ROR38280.1,
RC   ECO:0000313|Proteomes:UP000267408}, and DSM 44781
RC   {ECO:0000313|EMBL:RPE32002.1, ECO:0000313|Proteomes:UP000266906};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RPE32002.1}.
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DR   EMBL; RJVJ01000002; ROR38280.1; -; Genomic_DNA.
DR   EMBL; RKQG01000001; RPE32002.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3N4RF87; -.
DR   Proteomes; UP000266906; Unassembled WGS sequence.
DR   Proteomes; UP000267408; Unassembled WGS sequence.
DR   CDD; cd08287; FDH_like_ADH3; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR42813:SF2; DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED; 1.
DR   PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          25..132
FT                   /note="Alcohol dehydrogenase-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08240"
FT   DOMAIN          180..306
FT                   /note="Alcohol dehydrogenase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00107"
SQ   SEQUENCE   347 AA;  35860 MW;  B2C2AA677398FD24 CRC64;
     MRATVIHGPQ DIRIEEVPDP RIERPTDVVV RVLNACICGS DLWAYRGVSK RQAGQRIGHE
     FLGFVEEAGA EVRGFAVGDL VVAPFVWSDG VCEYCREGLQ TSCPHGGFWG TPGSDGGQGE
     AVRVPFADGT LVKLPKEAAG DAKLLPGLLA LSDVMATGHH AAVSAGVRPG ATVAVVGDGA
     VGLCGVLAAH RLGAGRIIAL GRHAGRTAIA RSFGATDVVP ERGEAAVEAV RELTGGQGAH
     AVLEAVGTEE SMRTALSIAR DGGAVGYVGV PHGGSAGVDI GQMFNRNVRL VGGVAPARAY
     IPELLPDVLS GAIDPGAVFD RTIGLDEVPE GYRAMDERTA LKVRIAF
//