ID A0A3N4RSB4_9ACTN Unreviewed; 472 AA.
AC A0A3N4RSB4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=GntR family transcriptional regulator/MocR family aminotransferase {ECO:0000313|EMBL:RPE35776.1};
GN ORFNames=EDD38_4133 {ECO:0000313|EMBL:RPE35776.1};
OS Kitasatospora cineracea.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Kitasatospora.
OX NCBI_TaxID=88074 {ECO:0000313|EMBL:RPE35776.1, ECO:0000313|Proteomes:UP000266906};
RN [1] {ECO:0000313|EMBL:RPE35776.1, ECO:0000313|Proteomes:UP000266906}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44781 {ECO:0000313|EMBL:RPE35776.1,
RC ECO:0000313|Proteomes:UP000266906};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the C-terminal section; belongs to the class-I
CC pyridoxal-phosphate-dependent aminotransferase family.
CC {ECO:0000256|ARBA:ARBA00005384}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RPE35776.1}.
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DR EMBL; RKQG01000001; RPE35776.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3N4RSB4; -.
DR Proteomes; UP000266906; Unassembled WGS sequence.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00609; AAT_like; 1.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46577; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR PANTHER; PTHR46577:SF1; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR Pfam; PF00392; GntR; 1.
DR PRINTS; PR00035; HTHGNTR.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW Aminotransferase {ECO:0000313|EMBL:RPE35776.1};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000313|EMBL:RPE35776.1}.
FT DOMAIN 29..97
FT /note="HTH gntR-type"
FT /evidence="ECO:0000259|PROSITE:PS50949"
SQ SEQUENCE 472 AA; 49123 MW; B6FFAB850DF8F4DB CRC64;
MGCWAGWSVG RCEVVGVREL LIAWEPGGGE LAGRLVRALR AAVREGRLAG GARLPASRVL
AAELGVSRGV VVEAYEQLAA EGYLVGRQGS GTRVAEGVAV ERPGEAVRVP AAEPRYDLKP
GTPDLGAFPR AAWAGAVRRA LQGAANRDLG YGDPAGLPQL RGELAAYLGR VRAVAAGPER
VAVISGVGQG LALLVGLLAR HGRRRIAVED PGSPGTLGLL RAHGVEPVGV PVDQEGLVVR
ELAASGADAV LVTPAHQYPT GVALSARRRT ELAGWARAGG LVVEDDYDAE FRYDREPLGA
VQGLAPERTV YLGSLSKTLA PGLRLGWAVL PGWLAEDFRQ AKQYADLGTG AVDQLAFAAL
LESGGYDRHL RAVRPRYRAR RDALVGALRE HLPQAGLRGV AAGLHLYADL PPGVDERELA
GAALRRGVRI APVGPGRLAP GGAAVALGYA GLAEQRLREA AALLGAACRE VG
//
