ID   A0A3N4VCL9_9BURK        Unreviewed;       507 AA.
AC   A0A3N4VCL9;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:RPE70664.1};
GN   ORFNames=EDC62_1150 {ECO:0000313|EMBL:RPE70664.1};
OS   Tibeticola sediminis.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Tibeticola.
OX   NCBI_TaxID=1917811 {ECO:0000313|EMBL:RPE70664.1, ECO:0000313|Proteomes:UP000272193};
RN   [1] {ECO:0000313|EMBL:RPE70664.1, ECO:0000313|Proteomes:UP000272193}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 101684 {ECO:0000313|EMBL:RPE70664.1,
RC   ECO:0000313|Proteomes:UP000272193};
RA   Goeker M.;
RT   "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT   most valuable type-strain genomes for metagenomic binning, comparative
RT   biology and taxonomic classification.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC       {ECO:0000256|ARBA:ARBA00005086}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RPE70664.1}.
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DR   EMBL; RKQL01000002; RPE70664.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3N4VCL9; -.
DR   OrthoDB; 5287258at2; -.
DR   Proteomes; UP000272193; Unassembled WGS sequence.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000272193}.
FT   DOMAIN          8..186
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          189..286
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          416..496
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   507 AA;  54670 MW;  0AD2BC8FFF69B704 CRC64;
     MTTPTYLNVG IVGAGVMGRG IAQVAAQAGS RVFLYDTNAE NLSVARAAVL DQWRRMVEKE
     RLTPAEAESL ATRLMACETL EALRDCDLVI EAIVERLDVK CELFATLEGI VAADATLATN
     TSSLSVTAIA ASLRHPGRFA GYHFFNPVPL MRVVEVVAGL RSDEATCRKL TQYARDMGHR
     PVRAQDTPGF IVNHAGRGYI TEGLRVVSEG VADFATVDRI LRDQVGFKLG PFELLDLTGL
     DVSQPVMESI YHQYYEEPRF RPSVIGAQRL AGKVLGRKTG VGFYRYEGGK PVVPDEPPTP
     GVAEMPPFWV SPRAARRSEL LALIHRLGGS IETGAAPSAQ AVTLVAPLGF DVTTVSVVER
     LDPARTVGID LLIDDAATRR RVLATNPATR RDVRDAAHAL FARDGKAVSV IRDSGGFVTQ
     RVLATVVNIG CDICQQGICT PEDLEAAVSL GLGYPAGPLG LGDRCGGTNI LEVLFNLQTV
     YGDPRYRPSP WLRRRGALGL SLTHTEA
//