ID A0A3N4Z277_9MICO Unreviewed; 327 AA.
AC A0A3N4Z277;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=UDP-glucose 4-epimerase {ECO:0000256|ARBA:ARBA00018569};
DE EC=5.1.3.2 {ECO:0000256|ARBA:ARBA00013189};
DE AltName: Full=Galactowaldenase {ECO:0000256|ARBA:ARBA00033067};
DE AltName: Full=UDP-galactose 4-epimerase {ECO:0000256|ARBA:ARBA00031367};
GN ORFNames=EDD32_0338 {ECO:0000313|EMBL:RPF25924.1};
OS Georgenia muralis.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Bogoriellaceae;
OC Georgenia.
OX NCBI_TaxID=154117 {ECO:0000313|EMBL:RPF25924.1, ECO:0000313|Proteomes:UP000280726};
RN [1] {ECO:0000313|EMBL:RPF25924.1, ECO:0000313|Proteomes:UP000280726}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14418 {ECO:0000313|EMBL:RPF25924.1,
RC ECO:0000313|Proteomes:UP000280726};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC EC=5.1.3.2; Evidence={ECO:0000256|ARBA:ARBA00000083};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC {ECO:0000256|ARBA:ARBA00004947}.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. {ECO:0000256|ARBA:ARBA00007637}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RPF25924.1}.
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DR EMBL; RKRA01000001; RPF25924.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3N4Z277; -.
DR OrthoDB; 9801785at2; -.
DR UniPathway; UPA00214; -.
DR Proteomes; UP000280726; Unassembled WGS sequence.
DR GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005886; UDP_G4E.
DR NCBIfam; TIGR01179; galE; 1.
DR PANTHER; PTHR43725; UDP-GLUCOSE 4-EPIMERASE; 1.
DR PANTHER; PTHR43725:SF51; UDP-GLUCOSE 4-EPIMERASE; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023144};
KW Galactose metabolism {ECO:0000256|ARBA:ARBA00023144};
KW Reference proteome {ECO:0000313|Proteomes:UP000280726}.
FT DOMAIN 4..252
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 327 AA; 34978 MW; BF059C3A08F632B3 CRC64;
MSTLVIGGAG YIGAHVVRLL LERGEDVVVV DDLSTGAADR VGAATLVELD VAGDGAQTSL
ERVMSERAVT SVIHFAARKQ VGESVARPAW YYQQNVGGLA NVLAAMENAG VRNMIFSSSA
AVYGMPPVEL VGEDVECRPI NPYGETKLVG EWLLADCGRA WGLRWTALRY FNVAGAGWPD
LGDPAVLNLV PMVLDRLERG DRPKIFGDDY PTPDGTCIRD YIHVLDLAQA HLAAMDHLTS
DAEPTEHVFN VGTGTGASVK EVVDEIGRAS GLDVTAEVEA RRAGDPPQLV AAADRIGEVL
SWKAEHGLTD IIRSAWEAWQ AGPRRIG
//
