ID A0A3N5CJH3_9STAP Unreviewed; 881 AA.
AC A0A3N5CJH3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=EDD62_0537 {ECO:0000313|EMBL:RPF57901.1};
OS Abyssicoccus albus.
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae.
OX NCBI_TaxID=1817405 {ECO:0000313|EMBL:RPF57901.1, ECO:0000313|Proteomes:UP000277108};
RN [1] {ECO:0000313|EMBL:RPF57901.1, ECO:0000313|Proteomes:UP000277108}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 29158 {ECO:0000313|EMBL:RPF57901.1,
RC ECO:0000313|Proteomes:UP000277108};
RA Goeker M.;
RT "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT most valuable type-strain genomes for metagenomic binning, comparative
RT biology and taxonomic classification.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RPF57901.1}.
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DR EMBL; RKRK01000002; RPF57901.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3N5CJH3; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000277108; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000277108}.
FT DOMAIN 680..696
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT COILED 483..517
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 606..613
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 881 AA; 101581 MW; 991F5AD92DC78820 CRC64;
MTEQTPMMKQ YLSIKSEYED CLLFFRLGDF YEMFFDDAKI ASKELEITLT ARDAKKENPI
PMCGVPHHSA NGYIKTLLDR GYKIAICEQM EDAKAVKGMV RREVVKVLTP GTAMDDYAID
NDEHHYVLCI DMVKEYYTLA YVDVTTGDCY FTQFDQNNQT LISEVMMINP KEIVVSDSTL
QLIPEMLKGQ YIIQIHHQLN PLDDIVQFEI SDLLKQQSVV QKLFNYIYSH QRHSLTHIKE
IEEYSLSKYM QMDSSVVMNL ELHESISTKK KKGSLFHLMD YTMTPMGRRL LKKWIDKPLI
SQNDIEKRQM KVHQFIEQFI ERDELREMLT GIYDIDRLAS RIAFNNANPK DIKQLEQSLL
NVQNCLTWML EHFNISFNVD IESTLQRLTD VFNLIDGAIV DNPPNQYTEG KLFNVGYDES
LDELRDISMN AEDWLLNYQQ QQRNDTGIKS LKVNYNKVFG YYIEISKAQL HSFDESHFGY
QRRQTLTNAE RFITDELKEK EQQIESAKEK SHQLEYELFI ELRSTLNEHI QSLQQIALLM
SEIDVLQSMA ELASQHHYVR PTFSKDKTLT LRNARHPIVE AVMNVEDYVP NDCNMNDQDY
IALLTGPNMS GKSTYMRQVG IISIMAQMGS YVPADEAVLP IFDKIFTRIG ASDDLAGGKS
TFMVEMMEAS VALTEATENS LIIFDEIGRG TSTYDGMALA KSMLEYIAKH IHAKTFFSTH
YHELTELEES LKPLFNIHVT AKQQNGHLFF LHKVMPGAVK KSYGIEVAKL AELPNEVIQR
ATTILSELES QQSTNIQEAS QRQDGTSIEL RTGGQSKVEK HVSEKVDEEQ LSFSTLFDTE
QVDMTKANKI IDMIEQFNLI EKTPLEAMNF IQSLKSSLKE E
//
