ID   A0A3N5Y0N1_9ALTE        Unreviewed;       521 AA.
AC   A0A3N5Y0N1;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 12.
DE   SubName: Full=Tryptophan 7-halogenase {ECO:0000313|EMBL:RPJ67032.1};
GN   ORFNames=DRW07_05665 {ECO:0000313|EMBL:RPJ67032.1};
OS   Alteromonas sediminis.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC   Alteromonadaceae; Alteromonas/Salinimonas group; Alteromonas.
OX   NCBI_TaxID=2259342 {ECO:0000313|EMBL:RPJ67032.1, ECO:0000313|Proteomes:UP000275281};
RN   [1] {ECO:0000313|EMBL:RPJ67032.1, ECO:0000313|Proteomes:UP000275281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=U0105 {ECO:0000313|EMBL:RPJ67032.1,
RC   ECO:0000313|Proteomes:UP000275281};
RA   Ye M.-Q., Du Z.-J.;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RPJ67032.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; RPOK01000002; RPJ67032.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3N5Y0N1; -.
DR   OrthoDB; 7178350at2; -.
DR   Proteomes; UP000275281; Unassembled WGS sequence.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006905; Flavin_halogenase.
DR   InterPro; IPR033856; Trp_halogen.
DR   PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR   PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR   Pfam; PF04820; Trp_halogenase; 1.
DR   PIRSF; PIRSF011396; Trp_halogenase; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   4: Predicted;
KW   FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW   Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000275281}.
FT   ACT_SITE        82
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT   BINDING         16..19
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT   BINDING         82
FT                   /ligand="7-chloro-L-tryptophan"
FT                   /ligand_id="ChEBI:CHEBI:58713"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT   BINDING         189
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT   BINDING         339
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT   BINDING         348
FT                   /ligand="L-tryptophan"
FT                   /ligand_id="ChEBI:CHEBI:57912"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT   BINDING         352
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ   SEQUENCE   521 AA;  58781 MW;  DF11358B335627D9 CRC64;
     MTSQIHPFRH LVIVGGGTAG WMAASLFQHA WARFGVEITV VESEKIGIIG VGEGSTPSLR
     HFFRTLGIAE TEWMAQCHAT YKCGIHFPNW SSHLSQNAYF HPFYSELDWK SGSAFIYNAN
     LRRKGYDVEA HPDYFWLQTK LAQGKRSPVS KQASGKELDY GYHFDSAKLG AYLKCRAIKL
     GIRHINDTVV AVKRAKEGHV TQIQLARTGA LCGDMYLDCT GFQGLLIRQA LNADYVDFSS
     QLLNDKAIAI PSSVPLKDKV ASQTTSTAMS NGWAWSIPLS NRVGNGYVYS SQHISDDSAE
     AELRRHIGSN VSQGEARLIN MQLGRVEQHW YHNVLAVGLS QGFIEPLEAT AISCIQYTIE
     RFIDIVDEAR TSGKEIASTH LQDKYNADIN RIFDAVKDYI TAHYRLNTRT DSQYWIDNRE
     NQDHSSTLQA LLSGWDDPDT HFEKLVHDLD AQTMYLAPSW YCLFAGKGRF PRTLRSVPLD
     TNYANAIDAS KYCQHQSTFF NDHKKQLLKT YGQHYPEPVT F
//