ID A0A3N5ZE04_9ALTE Unreviewed; 368 AA.
AC A0A3N5ZE04;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE RecName: Full=D-lactate dehydratase {ECO:0000256|ARBA:ARBA00013134};
DE EC=4.2.1.130 {ECO:0000256|ARBA:ARBA00013134};
GN ORFNames=DRW07_03475 {ECO:0000313|EMBL:RPJ68478.1};
OS Alteromonas sediminis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Alteromonadaceae; Alteromonas/Salinimonas group; Alteromonas.
OX NCBI_TaxID=2259342 {ECO:0000313|EMBL:RPJ68478.1, ECO:0000313|Proteomes:UP000275281};
RN [1] {ECO:0000313|EMBL:RPJ68478.1, ECO:0000313|Proteomes:UP000275281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=U0105 {ECO:0000313|EMBL:RPJ68478.1,
RC ECO:0000313|Proteomes:UP000275281};
RA Ye M.-Q., Du Z.-J.;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + methylglyoxal = (R)-lactate + H(+);
CC Xref=Rhea:RHEA:27754, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16004, ChEBI:CHEBI:17158; EC=4.2.1.130;
CC Evidence={ECO:0000256|ARBA:ARBA00001524};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RPJ68478.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; RPOK01000001; RPJ68478.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3N5ZE04; -.
DR OrthoDB; 9792284at2; -.
DR Proteomes; UP000275281; Unassembled WGS sequence.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR CDD; cd03141; GATase1_Hsp31_like; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR002818; DJ-1/PfpI.
DR PANTHER; PTHR48094:SF11; GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED; 1.
DR PANTHER; PTHR48094; PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED; 1.
DR Pfam; PF01965; DJ-1_PfpI; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 4: Predicted;
KW Glutamine amidotransferase {ECO:0000313|EMBL:RPJ68478.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000275281};
KW Signal {ECO:0000256|SAM:SignalP};
KW Stress response {ECO:0000256|ARBA:ARBA00023016};
KW Transferase {ECO:0000313|EMBL:RPJ68478.1}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..368
FT /note="D-lactate dehydratase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018191164"
FT DOMAIN 47..242
FT /note="DJ-1/PfpI"
FT /evidence="ECO:0000259|Pfam:PF01965"
SQ SEQUENCE 368 AA; 40213 MW; EE0FA03413785C61 CRC64;
MKVLIFVITA VFMSVSNAVA EPSKHVLMVL SSHGQQQGEE RPGYEFDEFA KAYLVFKQHG
ITVDIASPKG GVLVADEYDP KKPFNAQVIA DDHAMAKLNS SLPLHTLSAA HYDGVFVVGG
KGAMFDFPNN KALQTLITDI YQQQGSVAAV CHGPAALVNV RLNDGSYLIA NKAINGFTNE
EERMFGKKWM KEFDFLLEDK LIERGGKFQS SGFMLAHVAV DGRLITGQNP SSTVGVALEL
VKSLGVEVQP VEQYTDDKTM GLVAKLLNGE YKAIQPLITH AEAYNIKLVG MYGYYYMMKS
DTAQDYRNAL MLMNVAKEAI NSPNLEMQIA KAHQALGDSQ SAALVLHEIL ADQPAFKAAS
DMLVTLTQ
//
