ID   A0A3N6FIT1_9ACTN        Unreviewed;       594 AA.
AC   A0A3N6FIT1;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:RPK55742.1};
DE            EC=1.1.1.157 {ECO:0000313|EMBL:RPK55742.1};
GN   Name=fadB5 {ECO:0000313|EMBL:RPK55742.1};
GN   ORFNames=EES43_25740 {ECO:0000313|EMBL:RPK55742.1};
OS   Streptomyces sp. ADI96-02.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1522760 {ECO:0000313|EMBL:RPK55742.1, ECO:0000313|Proteomes:UP000273170};
RN   [1] {ECO:0000313|EMBL:RPK55742.1, ECO:0000313|Proteomes:UP000273170}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ADI96-02 {ECO:0000313|EMBL:RPK55742.1,
RC   ECO:0000313|Proteomes:UP000273170};
RA   Guerrero-Garzon J.F., Zehl M., Urban E., Schneider O., Ruckert C.,
RA   Busche T., Kalinowski J., Zotchev S.B.;
RT   "Streptomyces spp. from the marine sponge Antho dichothoma: analyses of
RT   secondary metabolite biosynthesis gene clusters and some of their
RT   products.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC       {ECO:0000256|ARBA:ARBA00005086}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RPK55742.1}.
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DR   EMBL; RPGW01000169; RPK55742.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3N6FIT1; -.
DR   OrthoDB; 9771883at2; -.
DR   Proteomes; UP000273170; Unassembled WGS sequence.
DR   GO; GO:0008691; F:3-hydroxybutyryl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 2.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000313|EMBL:RPK55742.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000273170}.
FT   DOMAIN          7..185
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          188..284
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          315..492
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          495..591
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   594 AA;  61928 MW;  73D72EE77AE0FD53 CRC64;
     MDIPLSTIAV VGLGTMGTGI AEVLVLAGRE VVGIDVSEAA GHQAAASLAA STARAVARGR
     ITERERADAL ARFRAFHDLG AAAGAELVIE VVPETYEIKQ QVFRELDAVV SPTAILATGT
     NALSVTRLAA ESRHPERVLG LHFFNPAPAM KLVEVVSSVL TAPLAVEAVT ALARELGKEP
     VAVGDRPGFV ADGLLFGYLN QAAAMYEAHY ASREDIDAAM RLGCGLPMGP LALLDLIGID
     TARTVLEAMY TASHDRLHAP APILGQLSEA GLTGRKAGRG FYTYAAPGGQ DVVPDALTPV
     AGVAAAGTGR PVSSVGVAGS GTMASGIAEV FAKAGFAVVL AARGQEKADL AKGRIAKSLE
     RSVSRGRLTA GARDETLARI TPAGSLDAFA EVDLAVEAVA EDLEVKRQLF AALDKVCRPG
     AVLATTTSSL PVIAVARATS RPQDVVGMHF FNPAPAMKLV EVVRTVLTSD DAHATVRALC
     AAVRKHPVDC GDRAGFIVNA LLFPYLNNAV KMVEEHYASL DDIDAAMKLG GGYPMGPFEL
     LDVVGLDVSL AIEKVLHREF RDPGLAPAPL LEHLVAAGCL GRKTGRGFRE YARR
//