ID   A0A3N6FR57_9ACTN        Unreviewed;       958 AA.
AC   A0A3N6FR57;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Regulatory protein AfsR {ECO:0000313|EMBL:RPK65810.1};
GN   Name=afsR3 {ECO:0000313|EMBL:RPK65810.1};
GN   ORFNames=EES43_07000 {ECO:0000313|EMBL:RPK65810.1};
OS   Streptomyces sp. ADI96-02.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1522760 {ECO:0000313|EMBL:RPK65810.1, ECO:0000313|Proteomes:UP000273170};
RN   [1] {ECO:0000313|EMBL:RPK65810.1, ECO:0000313|Proteomes:UP000273170}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ADI96-02 {ECO:0000313|EMBL:RPK65810.1,
RC   ECO:0000313|Proteomes:UP000273170};
RA   Guerrero-Garzon J.F., Zehl M., Urban E., Schneider O., Ruckert C.,
RA   Busche T., Kalinowski J., Zotchev S.B.;
RT   "Streptomyces spp. from the marine sponge Antho dichothoma: analyses of
RT   secondary metabolite biosynthesis gene clusters and some of their
RT   products.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC       {ECO:0000256|ARBA:ARBA00005820}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RPK65810.1}.
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DR   EMBL; RPGW01000029; RPK65810.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3N6FR57; -.
DR   Proteomes; UP000273170; Unassembled WGS sequence.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0098542; P:defense response to other organism; IEA:UniProt.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd15831; BTAD; 1.
DR   CDD; cd02019; NK; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR005158; BTAD.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR35807:SF1; TRANSCRIPTIONAL REGULATOR REDD; 1.
DR   PANTHER; PTHR35807; TRANSCRIPTIONAL REGULATOR REDD-RELATED; 1.
DR   Pfam; PF03704; BTAD; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF13424; TPR_12; 2.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM01043; BTAD; 1.
DR   SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 3.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000273170};
KW   Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT   DOMAIN          89..233
FT                   /note="Bacterial transcriptional activator"
FT                   /evidence="ECO:0000259|SMART:SM01043"
FT   DOMAIN          304..456
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   REGION          242..266
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        246..261
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   958 AA;  103135 MW;  36A90674DD41C4DB CRC64;
     MTGADGRVCR IPRGRQQVVL CALLLEANRI VSTESLVDAI WGTVPPSTAR TQIQTCISAL
     RTNLAAIREH TSLITQEPGY LLRVDDEQLD AKLFGVLTRR AQTLAEAGSP AEAADALRAA
     DDLCRGPALS GTKSLTLQAA AAHLDERRLA GLEAHAALRL QLGGHAALVP ELSALVAQHP
     LREGLRGQLM LALYRSGRQA EALETFRAGR LLLVEQLGIE PGDELRRLEA AILAGDGALH
     IADPATPPAP ATPPSRAPQP AAARPEPAIT AVPCQLPSDI GDFTGQAAVV NAARTALVAG
     DARATPVVVL TGPPGVGKST VAVHTAHRLA QHFSDGQLYC DLGGTRDEPA TALDVLGRFL
     RALGIPGSQL PESVDERASM YRDLLASRRV LVVLDSAADA RQVRRLLPGS GGSAVLVTGR
     SRMTGLPGAR FVPVGVFEPD EAIAMLAAVV GEERVGGEPE AARALVRLVG QMPLALRIIA
     ARLVARPHWS LEWMLNRLSN ERRRLDELAH GEMVIRSSLA LTYDGLGEEA RRLLRLLSVV
     EGGSIATWTA AALLDIDLFA ADDLLELLVD AQMLEVVDAA ARTGPQYRLH SLVQLFAREQ
     QERHSAEDDT DAALRRLVGG WLALVDEAHR RLYGGDFTVL HGDAPRWQPA LAQADRLLGD
     PLAWLEEERA NLCRAVDLAA SRGQAEACWD LAVTLVTLFE SRCYYDEWQQ THQRALDAVR
     DAGLSRGFAA VMCSVGSLCL GRAHLGAARR ALEPALEAFL ALDDTHGLAL TRRNLALLAV
     RQGDTDTARE LHERAAADFL AVADHVGRTN VLAHLARLAL GDERLDDAEE LLGEALEICR
     TTGSRRTEGQ VRLVLSDLMQ HRGRYQEAEE LLREVLEVVR SRGDIAGESR ILHQLGLVNA
     RLGRPGAAQA LLRDVVAIRE QIMDPVGAAE ARLELAQLEA KHRERLTGFE FPLISALG
//