ID A0A3N6GVY0_9ACTN Unreviewed; 351 AA.
AC A0A3N6GVY0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Alpha-pyrone synthesis polyketide synthase-like Pks11 {ECO:0000313|EMBL:RPK72582.1};
DE EC=2.3.1.- {ECO:0000313|EMBL:RPK72582.1};
GN ORFNames=EES45_32205 {ECO:0000313|EMBL:RPK72582.1};
OS Streptomyces sp. ADI97-07.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1522762 {ECO:0000313|EMBL:RPK72582.1, ECO:0000313|Proteomes:UP000281409};
RN [1] {ECO:0000313|EMBL:RPK72582.1, ECO:0000313|Proteomes:UP000281409}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ADI97-07 {ECO:0000313|EMBL:RPK72582.1,
RC ECO:0000313|Proteomes:UP000281409};
RA Guerrero-Garzon J.F., Zehl M., Urban E., Schneider O., Ruckert C.,
RA Busche T., Kalinowski J., Zotchev S.B.;
RT "Streptomyces spp. from the marine sponge Antho dichothoma: analyses of
RT secondary metabolite biosynthesis gene clusters and some of their
RT products.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RPK72582.1}.
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DR EMBL; RPGY01000155; RPK72582.1; -; Genomic_DNA.
DR RefSeq; WP_056788204.1; NZ_ML123100.1.
DR AlphaFoldDB; A0A3N6GVY0; -.
DR Proteomes; UP000281409; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877:SF99; 1,3,6,8-TETRAHYDROXYNAPHTHALENE SYNTHASE; 1.
DR PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:RPK72582.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000281409};
KW Transferase {ECO:0000313|EMBL:RPK72582.1}.
FT DOMAIN 6..198
FT /note="Chalcone/stilbene synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00195"
FT DOMAIN 215..350
FT /note="Chalcone/stilbene synthase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02797"
FT ACT_SITE 139
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
SQ SEQUENCE 351 AA; 37719 MW; F644FEBEE198325A CRC64;
MTRIAAVHGV LPPHRHTQQA VTDMVARTCL PAGTDRRVLD RIHRNARVRT RNTVLPLERY
GELDGFGAAN DVFIDAAVDL GARAVREALR EAGLRPADVD LLLFTSVTGV AAPSVDARLV
GRLGLRPDVK RLPVFGLGCV AGAAGVARLH DYLLGRPGQV AVLLSVELCS LTFQREDGTP
ANMVATALFG DGAAAVVLVG GRHARAEGPE VVDTRSRLYP DTGHVMGWDI RSSGFKVVLD
PAVPDVVRRY LADDVRGFLE EHGLKPKDVA HWVCHPGGPK VLEAVIEVLS LPEGALDVTW
RSLAEVGNLS SASVLHVLRD TLEQRRPEPG TPGLLMAMGP GFCCELVLLR W
//
