ID A0A3N6GXM2_9ACTN Unreviewed; 2437 AA.
AC A0A3N6GXM2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Tyrocidine synthase 3 {ECO:0000313|EMBL:RPK56889.1};
GN Name=tycC5 {ECO:0000313|EMBL:RPK56889.1};
GN ORFNames=EES43_23230 {ECO:0000313|EMBL:RPK56889.1};
OS Streptomyces sp. ADI96-02.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1522760 {ECO:0000313|EMBL:RPK56889.1, ECO:0000313|Proteomes:UP000273170};
RN [1] {ECO:0000313|EMBL:RPK56889.1, ECO:0000313|Proteomes:UP000273170}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ADI96-02 {ECO:0000313|EMBL:RPK56889.1,
RC ECO:0000313|Proteomes:UP000273170};
RA Guerrero-Garzon J.F., Zehl M., Urban E., Schneider O., Ruckert C.,
RA Busche T., Kalinowski J., Zotchev S.B.;
RT "Streptomyces spp. from the marine sponge Antho dichothoma: analyses of
RT secondary metabolite biosynthesis gene clusters and some of their
RT products.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RPK56889.1}.
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DR EMBL; RPGW01000152; RPK56889.1; -; Genomic_DNA.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000273170; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd17643; A_NRPS_Cytc1-like; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000273170}.
FT DOMAIN 1032..1106
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2081..2155
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2437 AA; 260241 MW; F6768235A42C1A09 CRC64;
MTTSDVRPGP LAPNGDQPPA RGDGGLSPAA RRLLQQRLSG VAAATADGPV RAAERPERLP
LSAAQRRLYF LDRLDPGAAT YLLPAAWRLA GPLDVPALRA AVAGLTARHE QLRVVFPEHD
GTPHQRVLPA GDDVLDVVDL TGPADGDREA LLAAAVRSAA TRPFDLARRP AFRATLVRAA
DDDHVLVLAM HHIVSDGWSL GLLVRDLGEL YAARTAGRVA DLPELPLDYT DYALWQDRAD
HTAELAHWRT RLEGLTPLEL PADHPRPDAP GGDGAAHTLT LPAALADELA ELGRRTGATA
YMIVLAAFQA ALAFRSGQDD IAVGTVVANR ERPEIEQLVG FFVNTLVLRA DLSDDPTPAA
FLARTRESAL DAFSHQTLPF EQVVDALSPE RDLARNPLVQ VLFTHSSAEP GGLALGGVHG
VPYRIDLTTA KFDLALELRD GHGPAELVFV YRSDLYDAAS VSSLAQHTVT FLEAFCRTPD
TPLGSIDPLT AEERAGLLGP DGPANAGPPA APAPRTAPER LAEHIARTPH AAAVSGSGRT
LTYAELDAAA SALARRMRAA GVAPGSLVGV CLERSPDLAV ALLAVWRTGA GYLPLDPAHP
HARRAFTVAD AGIDWIVADA ASRAAAEALP AGVIPLEADD DALRARDEAG AGGDLRPAPD
DLAYVIYTSG STGRPKGVEI THANLAWLLD AADRHFDFGP SDVWTQVHSP AFDFSVWELW
TPLTSGGRVV VLDADQVRDP AAVHRVLREE GVTVLNQTPA AFKGLRAQVA GGEAGFADLP
LRTVVFGGDA FDVRDYRDWF AAPGPKPDLV NMYGITETTV HVTFGRVTED DVRGTVRSPI
GRPLTGQHGY VLDARGRLVP PGSTGELYVS GGGVARGYRN RPELTAERFL DDPFGAPGGR
MYRTGDLVRV ERDGRLGYVG RADHQVKIRG YRIEPGEIET VLRALSGVAD AAVVARPERD
GARLVAHVVT TEGRPLDAPA LREGLRLQLP DHMVPALFVR HPRLPLTANG KVDRAALTAI
TPAAAARGGH VPPEGPVESV LAGVWAQVLG AEHVGRTDNF FDLGGDSILA LRVVGLARQG
GLALTIADVF RARTLADLAG AATEAREAPE PVAPFTQLDP ADADRLPEGL EDAYPLTMLQ
AGMLHEMLAD PLHGAYHNVT DLKITVPEGF DRAAFQAAVD AAVAGHGILR TSVDLVSYRE
PLQLVHRGAH LPVGYTDLRG LPREDQRARL RRFVDEEFDH RFDLSAAPLV RIHLHHVTDT
ELRLVLTDCH VVLDGWSLTS LVADLLELHR QAVAHRTAPR PPSAPAFAEY VALERAALHS
EPSLDYWRGR LADLRPVSFA RRADADAGQQ PLYEVRRSYA DLAEPIGRLA REAGVPRRTV
LIAAFHHTMS LFAQRDDSAL GHSIGLVTNG RPEVPDADRM RGLFLNTVPF GVARPRGSWI
DYLRDVFATE QEMLPHRRVP LVRIAQLRPT EPGLVDAVFN YVNFHRLTHD TWDDSLEIAR
TLFPLLVNAS VNGFTLDADP DRVPPATAEQ LADVLCAQLA AMVADPQARV TRPALTGPAR
TTVLEDWARG PELPSSPLLF HEHIAVHAAR TPNAVAVEGC GETLTYGELV EQADELAQTL
RGLGVGPETV VGICAERGCD LVRAAVGVLR SGGAFLPLDA QHPTERLEFM VRDSGMRVLL
TQRPLAGTVP FDGPVLHLDA EPDAPLPAPA AAPTTGPVEA DADTVAYIIY TSGSTGTPKG
VAIPHRGLSN MLEGQRDLVG PLATDRVLQF ASFGFDASVL ELTWALANGG RLVTAPRQAL
RPGPDLAETL RGGRVTGAML PPSALAVLGE DAFPDLRVLQ VAGEACPAEL ADVWARGRRF
QNVYGLTETT VWSVAADLSP GRGRPPIGSP IRNTRVHVLD DDLQPVPVGV PGEIHLGGRA
VGRGYLGRPA LTAAAYVPDP YGAPGERLCR TGDLGALRPD GTVEWLGRRD SQVKLRGFRI
ELGEIEHALR RLPEVRQAVV LHRTDLPGEP ALVAYLVTDG SPGAEPRELR LALRSSLPGY
MVPARFVVLD AMPVNTSGKI DKRALPLPPA DRAESDIAYV APATPAEKTL AEVWREVLGL
SRIGVDDDFF RIGGSSLSTV RVSLMAAARG LTVSVGDLIE HPTIARLADH VTRTATAELP
AAVTSRVRLR DGEGAPLWCV HPTGGSAAWF VPLARALPPG RPVHAFQARG LLGGVDPSTV
AGIAANYVGE MAEGEGQGPH ELLGWSMGAN IALEMATQLH EGGHRVAPLV LIEPYLPNPA
ARARLTGVAR ELREALRMRD RLRSLPPSPR RDTAAAELTA ALLGAGMSPT EASLVEDAPI
EVWHSLLAAL AAYEVRPYPG HVHLVVGSEA AGLPAGRTMP GLDVDYATYV ERWRAVAGDG
LTLHVSDGDH MSVLAGPRAA NIARLLDSVA TAPEEGR
//