ID A0A3N6HFC3_9ACTN Unreviewed; 1019 AA.
AC A0A3N6HFC3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Regulatory protein AfsR {ECO:0000313|EMBL:RPK83176.1};
GN Name=afsR3 {ECO:0000313|EMBL:RPK83176.1};
GN ORFNames=EES45_07725 {ECO:0000313|EMBL:RPK83176.1};
OS Streptomyces sp. ADI97-07.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1522762 {ECO:0000313|EMBL:RPK83176.1, ECO:0000313|Proteomes:UP000281409};
RN [1] {ECO:0000313|EMBL:RPK83176.1, ECO:0000313|Proteomes:UP000281409}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ADI97-07 {ECO:0000313|EMBL:RPK83176.1,
RC ECO:0000313|Proteomes:UP000281409};
RA Guerrero-Garzon J.F., Zehl M., Urban E., Schneider O., Ruckert C.,
RA Busche T., Kalinowski J., Zotchev S.B.;
RT "Streptomyces spp. from the marine sponge Antho dichothoma: analyses of
RT secondary metabolite biosynthesis gene clusters and some of their
RT products.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC {ECO:0000256|ARBA:ARBA00005820}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RPK83176.1}.
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DR EMBL; RPGY01000034; RPK83176.1; -; Genomic_DNA.
DR RefSeq; WP_056789715.1; NZ_ML123098.1.
DR AlphaFoldDB; A0A3N6HFC3; -.
DR Proteomes; UP000281409; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15831; BTAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR005158; BTAD.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR35807:SF1; TRANSCRIPTIONAL REGULATOR REDD; 1.
DR PANTHER; PTHR35807; TRANSCRIPTIONAL REGULATOR REDD-RELATED; 1.
DR Pfam; PF03704; BTAD; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF13424; TPR_12; 2.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM01043; BTAD; 1.
DR SMART; SM00028; TPR; 6.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000281409};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 30..98
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|SMART:SM00862"
FT DOMAIN 105..249
FT /note="Bacterial transcriptional activator"
FT /evidence="ECO:0000259|SMART:SM01043"
FT REPEAT 817..850
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 1019 AA; 110062 MW; 88BD214FD4D47DFF CRC64;
MGEDTGVHAI RFRILGSFEC WDGPDRVRVG GPVHEKVLVT LLLEPQRVLP VHRLVEAAWD
ENAPATAAHQ VRKAVAELRQ RIPGGRNLIV TEGPGYRALT TPEQVDLSRF TEGLKQAREA
TAAGQNAYAA TALREALDLW RGPLLSGSGG SVLCAASAAL EERRLTAVEQ LFDLRLAAGE
NGELIGELRE FIEANPLRET LRGQLMLALF RSGRQAEALE EFAKVREYLV DELGIGPGDA
LTDLHHAILR NSPELAAPAQ AAGPAPFTPE GSPSTLPYDL GDFTGREEEV SQLLGFVEEA
PGTGPLIVAI DGMGGSGKTS LAVRAAHQLT ERYPDAQLHI DLRGFTPSEQ PLTAGAAAEA
LLRMLGAPGE RIPDDAEGRI ALWRRTMSSR RMILLLDNAV DESQIRPLLA SPTQTLVLVT
SRALLADLDA AHTVSLGVMP PHDSVALVEG VLGSSRARAE PEAVAQLAEL CGHLPLALRI
AAARLRKRPR WTVRYLVDRL RDDAHRLAEL NSGERSVEVT LRLSYEGLSA ETREAFRLLG
QHPGAEIEVY AAGALLDKRA RDAEDVLEYL LDMHLLQQHE TGRYAFHDLV RSFAQNLSRV
GGRAGPETGD GDGDAGNEEA ALAVRRLLDF ALGATDAACD LLFPGRARIH RPEHRSTAEL
PPLNTSDQAR DWLEREQDSL LAAVSLAYRW ELDSHVGLLA ANVVFPLDLR GRLEEFRELC
RTAVTASRRL GDPALLRLSL SNLAVACWKL GRFEEGIEMA EEAFGLAVSL ADRRGEAKDT
GVLGLLLGAL GRYGEALPRL EHSIAIKREL GAERAEAESL ANLSKLYAEW GRFPEAVEAA
DRAVALSRSI GAVDKEVEGL TDLAVARLGL DAVDEAADLL RRARKLAVDV MSPADMSLLL
ALSAETADRL GESTQATEWA EAALQLGDLS GAPMREAAVG NIVGRLHARR GRFTLALELH
QQAHRAASGV DYRVEEARAL AGMAHAMERL GDHEAARTHL ATAEAAYDTM GIPAAGRTD
//
