ID   A0A3N6I1X6_9ACTN        Unreviewed;      1422 AA.
AC   A0A3N6I1X6;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=tRNA(Glu)-specific nuclease WapA {ECO:0000313|EMBL:RPK71489.1};
DE            EC=3.1.-.- {ECO:0000313|EMBL:RPK71489.1};
DE   Flags: Precursor;
GN   Name=wapA3 {ECO:0000313|EMBL:RPK71489.1};
GN   ORFNames=EES45_34375 {ECO:0000313|EMBL:RPK71489.1};
OS   Streptomyces sp. ADI97-07.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1522762 {ECO:0000313|EMBL:RPK71489.1, ECO:0000313|Proteomes:UP000281409};
RN   [1] {ECO:0000313|EMBL:RPK71489.1, ECO:0000313|Proteomes:UP000281409}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ADI97-07 {ECO:0000313|EMBL:RPK71489.1,
RC   ECO:0000313|Proteomes:UP000281409};
RA   Guerrero-Garzon J.F., Zehl M., Urban E., Schneider O., Ruckert C.,
RA   Busche T., Kalinowski J., Zotchev S.B.;
RT   "Streptomyces spp. from the marine sponge Antho dichothoma: analyses of
RT   secondary metabolite biosynthesis gene clusters and some of their
RT   products.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RPK71489.1}.
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DR   EMBL; RPGY01000165; RPK71489.1; -; Genomic_DNA.
DR   Proteomes; UP000281409; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   Gene3D; 2.60.120.200; -; 3.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR006558; LamG-like.
DR   InterPro; IPR042837; PTX3.
DR   PANTHER; PTHR46943; PENTRAXIN-RELATED PROTEIN PTX3; 1.
DR   PANTHER; PTHR46943:SF1; PENTRAXIN-RELATED PROTEIN PTX3; 1.
DR   Pfam; PF13385; Laminin_G_3; 3.
DR   SMART; SM00560; LamGL; 2.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
PE   4: Predicted;
KW   Hydrolase {ECO:0000313|EMBL:RPK71489.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000281409};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          795..937
FT                   /note="LamG-like jellyroll fold"
FT                   /evidence="ECO:0000259|SMART:SM00560"
FT   DOMAIN          1016..1159
FT                   /note="LamG-like jellyroll fold"
FT                   /evidence="ECO:0000259|SMART:SM00560"
FT   REGION          249..286
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1177..1196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1182..1196
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1422 AA;  150599 MW;  77851D5CDD54DD5C CRC64;
     MWARTQGVGR IVGVLLGVAL VVVTVPPVVS EAVAAEPGSS QTVAEQPTDD DVGTLTEAEA
     MTKAKKTGES VEIVSLRAES SEVYATPEGD LQAREYLRPV WTRTQGGWVR VDTNLAVTGD
     GMVAPKAATL DVEFSAGGEA PLVRMRRAGR ELSLTWPTPL PKPELAGTVA TYSSVLPDVD
     LRMTAQEDGF TQLLVVKTAE AAASEELAKL HLGLDTKGVS VEETSIGGLE AIDRGANGAV
     FEAPKPMMWD SSPGESPAGA ARSRTAAAEG SAAAGTEPGA GESGKLAPVD VEVPEGQKTL
     VLTPDANVLR GQDTTYPVYI DPQWYAPSAS AWTMASKYWA NSPQWKFNGD SDAGMGYCNW
     TYCNPHDTKR LMYRIPTSRF AGKSILSAEF VVGNTWSASC TNKAVDLYQT KAISSSTTWN
     DIYDTGFFVK KLGSESFAYG HSGCAAKDAE FNVKSALQAA ANAKTSTLTF GLKAENESDA
     YGWKRFSDEA HLRVEYNRAP TQIKMSQLTM EYGGTCKKPA SAAHVRTMGT LRANSVTDPD
     GDSVRVQFQA AWDSGDGKGL IARWSPALTS AKKSGSSFSI TLPASVPTNR QVNWYARTYD
     GAQYSPWSYA GDEPTGCYFV YDTSVPKAPA LSSGEYPASD PEDPDDPWFD GVGKYGEFSL
     KAAEPDVTKY WYGLNSDPSS KNTLTTVGGA AKTVQVLPAE PGLNFMTAQA FDAAGNGSEV
     RTYQFRVKAG QPERAAWQLD ESVGATVAQG SSGARVAALR GGALSGVPGV KGSAVSFDGV
     DDYAVTDIPT VNTENGFSVS AWVKLSQVPD HAAIVAAQPG NHSPGFELYY SHSYDRWVFN
     QYASDSPGAP VVRAMAPQAG GVNADRWTHL VGVYSGSTKD LRLYVDGTLT GTTPYSTAWD
     ARRGLQIGAG SYSGSPASFL PGQIDEIRIF DKPVSPTEVG HLFRHEGIGG GRTARTVFSL
     DETSGALEVT GRADTQPLSL AGDARLGATG VAGKALKLDG TGDYARTAAP HIDTQRPFTV
     SAWAKLDRVP AEGATVVAQL GQNRPGFELY YSKSYNRWGF TQYSGDVPGA TQVRAVQPDG
     TSARVGEWVH LVGVHDATAN TLTLYVNGVK SASVAQSAAW YAGGPVQAGA LSIDGGSLIQ
     YFPGTIDDIR MFDRPVAEDE VRQLFRQRPI VKARWKFDQP GGTSTPDDSG AGNHLTLGGG
     TQLGSGWVDG GLILDGVNDY ASSTTAPVDT STSFTVTAWA QAAAVPQSGV TLLSMPGTQQ
     NAFAVRYLPS ATPDTDSGRW RISVHDDDSA GANSIDVENG QFFSAADWTH LALVYDGFTK
     HLSLYINGEL EQVACADDDS DGQADDTACT DRLSWTDNVL AFKSAQPLQL GRAKTGTSSW
     GGYWPGAVSD VWAFQGTLTG RQVRHLAVGM PGLPTDVPGG DA
//