ID A0A3N6IX10_9ACTN Unreviewed; 353 AA.
AC A0A3N6IX10;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Fatty acid desaturase {ECO:0000313|EMBL:RPK85675.1};
DE EC=1.14.19.- {ECO:0000313|EMBL:RPK85675.1};
GN Name=des {ECO:0000313|EMBL:RPK85675.1};
GN ORFNames=EES45_00845 {ECO:0000313|EMBL:RPK85675.1};
OS Streptomyces sp. ADI97-07.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1522762 {ECO:0000313|EMBL:RPK85675.1, ECO:0000313|Proteomes:UP000281409};
RN [1] {ECO:0000313|EMBL:RPK85675.1, ECO:0000313|Proteomes:UP000281409}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ADI97-07 {ECO:0000313|EMBL:RPK85675.1,
RC ECO:0000313|Proteomes:UP000281409};
RA Guerrero-Garzon J.F., Zehl M., Urban E., Schneider O., Ruckert C.,
RA Busche T., Kalinowski J., Zotchev S.B.;
RT "Streptomyces spp. from the marine sponge Antho dichothoma: analyses of
RT secondary metabolite biosynthesis gene clusters and some of their
RT products.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the fatty acid desaturase type 1 family.
CC {ECO:0000256|ARBA:ARBA00009295}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RPK85675.1}.
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DR EMBL; RPGY01000004; RPK85675.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3N6IX10; -.
DR Proteomes; UP000281409; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016717; F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProt.
DR CDD; cd03506; Delta6-FADS-like; 1.
DR InterPro; IPR005804; FA_desaturase_dom.
DR InterPro; IPR012171; Fatty_acid_desaturase.
DR PANTHER; PTHR19353:SF19; DELTA(5) FATTY ACID DESATURASE C-RELATED; 1.
DR PANTHER; PTHR19353; FATTY ACID DESATURASE 2; 1.
DR Pfam; PF00487; FA_desaturase; 1.
DR PIRSF; PIRSF015921; FA_sphinglp_des; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000313|EMBL:RPK85675.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000281409};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 47..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 73..332
FT /note="Fatty acid desaturase"
FT /evidence="ECO:0000259|Pfam:PF00487"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 353 AA; 39123 MW; D33C105ADED40893 CRC64;
MPQAVATVAQ NTRDGSEDPA GRQASGSDFA PLLKTVKGQG LLDRRTGWYA AGIAVNLVAL
GAVITGMALL GDTWWNLFLA LPLAIVWTRT AFVGHDAGHA QITGDRKASR IIGFVHANLL
LGMNEAWWND KHVRHHANPN HIDKDPDVGV GALVWTQKQA AEREGFLRWL TRNQARLFFP
MLLLEGIALK IYGFQYLRNQ PVRERALSGL LLVGHLALYA TLLLTVMSPG KAVVFALVHH
ALFGLHLGMA FAPNHKGMEM PDPDGDRWGH LQRQVLTSRN VRGAFLTDWF LGGLNYQIEH
HLFPSMPRPH LRLAQPLVKA HCAEMGMPYA ETGLIESYRQ ALAHMHEVGE PLR
//
