ID   A0A3N6NZ44_9CYAN        Unreviewed;       839 AA.
AC   A0A3N6NZ44;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 10.
DE   SubName: Full=HDIG domain-containing protein {ECO:0000313|EMBL:RQH57594.1};
GN   ORFNames=D5R40_00190 {ECO:0000313|EMBL:RQH57594.1};
OS   Okeania hirsuta.
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC   Oscillatoriales; Oscillatoriaceae; Okeania.
OX   NCBI_TaxID=1458930 {ECO:0000313|EMBL:RQH57594.1, ECO:0000313|Proteomes:UP000269154};
RN   [1] {ECO:0000313|EMBL:RQH57594.1, ECO:0000313|Proteomes:UP000269154}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PAB10Feb10-1 {ECO:0000313|EMBL:RQH57594.1,
RC   ECO:0000313|Proteomes:UP000269154};
RX   PubMed=30444349;
RA   Moss N.A., Leao T., Rankin M., McCullough T.M., Qu P., Korobeynikov A.,
RA   Smith J.L., Gerwick L., Gerwick W.H.;
RT   "Ketoreductase domain dysfunction expands chemodiversity: malyngamide
RT   biosynthesis in the cyanobacterium Okeania hirsuta.";
RL   ACS Chem. Biol. 0:0-0(2018).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RQH57594.1}.
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DR   EMBL; RCBY01000001; RQH57594.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3N6NZ44; -.
DR   OrthoDB; 9806952at2; -.
DR   Proteomes; UP000269154; Unassembled WGS sequence.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR006675; HDIG_dom.
DR   InterPro; IPR011624; Metal-dep_PHydrolase_7TM_extra.
DR   InterPro; IPR011621; Metal-dep_PHydrolase_7TM_intra.
DR   NCBIfam; TIGR00277; HDIG; 1.
DR   PANTHER; PTHR36442; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR   PANTHER; PTHR36442:SF1; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR   Pfam; PF07698; 7TM-7TMR_HD; 1.
DR   Pfam; PF07697; 7TMR-HDED; 1.
DR   Pfam; PF01966; HD; 1.
DR   SMART; SM00471; HDc; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   PROSITE; PS51831; HD; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000269154}.
FT   DOMAIN          612..759
FT                   /note="HD"
FT                   /evidence="ECO:0000259|PROSITE:PS51831"
SQ   SEQUENCE   839 AA;  93172 MW;  249EDE5B5F933454 CRC64;
     MHLTHLIGKL LKPQKKQQLS SWSTLATSPI LVVLTIASLT GTMGQRYYSQ PKLDEGTVAP
     QTIRAPKGAI VPDNKVTEQQ RKSARLGDIT VLMINESVNQ RVDKELAEIL ALGNQVREIV
     VNFPFVNTGI LSTNTQLHLQ QVSQEKWVAI QQIVEEELKE RPPGPQPGIN ADSILTKNSI
     ELVSNNDNVI DDRLLTKVSV LADYQEYSQN SIVISSKDRQ AISELLAYRK KSFFQNYERV
     LEEISQARDL YKDATEYLAK QQEIEGYEVY DSTLLELSDT DWQKTQTGIE IVKERMLAQG
     ISPNLPKQEW VKALKLQVND VVPVVAEDLA INVLKVALEA NLSLDSEGTK QSVELAAQEI
     ETVTYKVRKN EVIVRKGKNI SRKAFVLLDH FRLSRRTVNW HGLGVLVGIV SGAVGIVVLV
     ERQFKSGLRH RDNILLLLLS LSAPLLIALK VPWSSLPAIG LLVGTFYGST MGVTVVGLIS
     VILPIGMDVD KIDWFASAAG AIVGSVIAEK MRSREEQALL GLGVGLTQGT VYLLINLIVR
     ETPGLLWYAI IGPVGSQAVT GAVTGLVWSI VALGLSPYLE HLFDLITSIR LSELANPNRP
     LLKRLASEAP GTFQHTLFVA SLAEAAARAI GCNVELVRTG TLYHDIGKMH DPLGFIENQM
     GGPNKHDEIK DPWVSVEIIR KHVTEGLVMA RKHRLPKAIR AFIPEHQGTM LIAYFYYQAK
     QRSEKGEKVV KEEMFRYAGP IPQSRETAIV MLADSCEAAL RSLKDVTHKD ALQMVKKIMR
     ARWQDNQLAD SGLTRAEMST IAEIFVQVWE QYNHKRIAYP KAAMNPNQVK TVKSVVSSN
//