ID A0A3N6X526_9ACTN Unreviewed; 904 AA.
AC A0A3N6X526;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=DUF4040 family protein {ECO:0000313|EMBL:RQN08763.1};
GN ORFNames=EHW97_05810 {ECO:0000313|EMBL:RQN08763.1};
OS Aeromicrobium camelliae.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Aeromicrobium.
OX NCBI_TaxID=1538144 {ECO:0000313|EMBL:RQN08763.1, ECO:0000313|Proteomes:UP000275225};
RN [1] {ECO:0000313|EMBL:RQN08763.1, ECO:0000313|Proteomes:UP000275225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YS17T {ECO:0000313|EMBL:RQN08763.1,
RC ECO:0000313|Proteomes:UP000275225};
RA Li F.;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000320}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU000320}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RQN08763.1}.
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DR EMBL; RQJX01000005; RQN08763.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3N6X526; -.
DR OrthoDB; 9811798at2; -.
DR Proteomes; UP000275225; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR007182; MnhB.
DR InterPro; IPR025383; MrpA_C/MbhD.
DR InterPro; IPR046806; MrpA_C/MbhE.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR43373:SF1; ANTIPORTER SUBUNIT MNHA2-RELATED; 1.
DR PANTHER; PTHR43373; NA(+)/H(+) ANTIPORTER SUBUNIT; 1.
DR Pfam; PF13244; MbhD; 1.
DR Pfam; PF20501; MbhE; 1.
DR Pfam; PF04039; MnhB; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR PRINTS; PR01434; NADHDHGNASE5.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000275225};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000320};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 31..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 73..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 124..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..459
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 479..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 552..574
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 580..599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 606..624
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 630..651
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 663..684
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 762..788
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 794..814
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 826..848
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 860..887
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 58..102
FT /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00662"
FT DOMAIN 121..410
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
FT DOMAIN 589..653
FT /note="MrpA C-terminal/MbhD"
FT /evidence="ECO:0000259|Pfam:PF13244"
FT DOMAIN 666..742
FT /note="MrpA C-terminal/MbhE"
FT /evidence="ECO:0000259|Pfam:PF20501"
FT DOMAIN 769..884
FT /note="Na+/H+ antiporter MnhB subunit-related protein"
FT /evidence="ECO:0000259|Pfam:PF04039"
SQ SEQUENCE 904 AA; 92914 MW; DEE60DF878CE9AD5 CRC64;
MTLLGLLLGG WLLTALAPLL ARWLGHRAGW PLAAGLLGLA AMALMLGYDT TVEQSVPWIP
SLDIALRLRL DGLAMLFVAL VLIVGALVMI YSTAYFRGKP TVSYYTLMTA FAASMTMLVL
ADDLVLLFVS WEFTTLCSYL LILRSGPDAG PPAARTLLVT VAGGLCLLAA VATIVVRTGT
THLSTALADP AWSEDGTFAT TVAILVAVAA MTKSAQFPFH AWLPDAMVAP APVSAYLHAA
AMVKAGIYLL LRFAEPAAHA PAWSALLITV GLVSSFIGAV FALQRTDLKA LLAYSTVSHL
GLLTLVIGVG TTAALTAAVV HVVAHAAFKS AGFLYVGLLE KRAGTRDIRE VGGLWRSMPL
ASVLILVAAV AMGGIPPTLG FVSKELVLDG VLHGPGLWLA ALVALSAAIT VAYSGRMVVS
TLPGAPTRLA PASGTWPMVV AIAIGAVAAG TFGLVAPALD PLVGRAVAAT GGSGDVHLAL
WHGVTPALGL SLAAIAAGAL LIVARRGVDR VLDRRLFPVT GVGAVEAVQR AVQVTGRRLG
DLTRTDAPAA HLAVPLLLIA VLGVAGLVAL TPSWEAADST AVDVALLIVL TGGVIATVVA
RSRLGAVIAV GVAGFSVAVW FFTLGASDVA LTQLLVEILT VVIMVLVLRH LPQQFGRRSV
RRAVPAAILA IAAGVVATLG PLVFTGRAEL SAVGRWFVEE GPVETGGANV VNTILVEFRA
LDTFGELVVL AIAALAITAL VEARPRVTRP VLPSVSSLLA PAAPNAVFIN VLARVLVPLM
LLGSLYALLR GHNAPGGGFI AALIGAGALA TRYLGAPDDR EAHSGLPYLA IAGSGVVVAA
VSGFIGYAER SFLTPLHADI LGYHFTTSLI FDLGVYLAVF GVILGALDSL GSPEEPAAKA
GDRR
//
