ID A0A3N7ERD5_9BURK Unreviewed; 936 AA.
AC A0A3N7ERD5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Peptidase M4 family protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=DBR47_09925 {ECO:0000313|EMBL:RQO59704.1};
OS Paucibacter sp. KBW04.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sphaerotilaceae; Roseateles.
OX NCBI_TaxID=2153361 {ECO:0000313|EMBL:RQO59704.1, ECO:0000313|Proteomes:UP000274884};
RN [1] {ECO:0000313|EMBL:RQO59704.1, ECO:0000313|Proteomes:UP000274884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KBW04 {ECO:0000313|EMBL:RQO59704.1,
RC ECO:0000313|Proteomes:UP000274884};
RA Lee F., Williams K.B., Levin M., Wolfe B.E.;
RT "The microbiome of the planarian worm Dugesia japonica mediates outcomes of
RT regeneration via indole production.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M4 family.
CC {ECO:0000256|ARBA:ARBA00009388}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RQO59704.1}.
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DR EMBL; QAJN01000008; RQO59704.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3N7ERD5; -.
DR OrthoDB; 5378341at2; -.
DR Proteomes; UP000274884; Unassembled WGS sequence.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04818; PA_subtilisin_1; 1.
DR Gene3D; 3.10.170.10; -; 1.
DR Gene3D; 3.10.450.490; -; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR InterPro; IPR011096; FTP_domain.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR023612; Peptidase_M4.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR InterPro; IPR001570; Peptidase_M4_C_domain.
DR InterPro; IPR013856; Peptidase_M4_domain.
DR PANTHER; PTHR33794; BACILLOLYSIN; 1.
DR PANTHER; PTHR33794:SF1; BACILLOLYSIN; 1.
DR Pfam; PF07504; FTP; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF01447; Peptidase_M4; 1.
DR Pfam; PF02868; Peptidase_M4_C; 1.
DR PRINTS; PR00730; THERMOLYSIN.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR SUPFAM; SSF52025; PA domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000274884};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..936
FT /note="Peptidase M4 family protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018181969"
FT DOMAIN 113..154
FT /note="FTP"
FT /evidence="ECO:0000259|Pfam:PF07504"
FT DOMAIN 255..359
FT /note="Peptidase M4"
FT /evidence="ECO:0000259|Pfam:PF01447"
FT DOMAIN 460..536
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 553..670
FT /note="Peptidase M4 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02868"
FT ACT_SITE 352
FT /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
FT ACT_SITE 604
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
SQ SEQUENCE 936 AA; 95745 MW; B2F6DBCBEC8F5642 CRC64;
MTRIHLKLSV LALAAGMALT AQAASTGSLV GQRDALARLG TDSGMAPKVS YNSATGAVGF
VRLAQGNTRS AASARPVADE ELRRGAAQFL SSYGSMFGLS NSASELSAGQ LVKDRYGAAH
LSQKQLYQGV PVFGAELKSH FDAAGKLTVV NGTFVPGIEL NATPTRSAAE AAAAAKKIVV
AELSSAAAAK VGTSKPTLMV YREGLAKGVE GANHLAWQVE VGNGSNVREF VFVDAHSGKV
IERIAGIHEG KNRRAFDAGN TTQPGPNYPN APFWVEGNPF PTGNTEADNM IAASGEIYDL
FKTAFGRDSF NGLGATMDSI FNRGNGCPNA SWNGVYISFC PGTTTDDVTA HEWAHAYTEY
THGLIYAWQP GALNEAYSDI WGETVDRING RGGDTPDTLR TAGACTASSS VAQVNIQSPA
AIAGVRNAGT AAFGPQSFSL STQDVVVVND GVTTSGSSLT DGCSTPFVNA AAVAGKIAFV
DRGTCGFAVK VKNAQLNGAV GVIVGNNAAG TINMGGSDAT ITVPSLSVTQ ADGTAIKAQT
GVTASLLRGP GSDNSVRWLV GEDSSAFGGA IRDMYNPTCY GNPGKVSDAQ YACGPITSDQ
GGVHSNSGVP NHAYALLVDG GSYNGQTVSA IGLTKAAHIY YRAQSVYQSQ ASGFPEHADA
IEQSCADLTG ISLAALKSGM PAGEVITSSD CQQVAKAALA VELRTPPAQC GFQTLLGQNP
PAQCPVGNPT VIAADGFDGG KRGGLKWTLS NGGIAGGSFT PRNFGVVNKL PSGRPGYAIY
AADINGGSCG GTGSEAGVQR LESPEITIPA GASTLRMSFD HWVSTEAGYD GANLKISVNG
GAWTLVNAAD FIYNPYNTTL TTAAAGNDNP LAGQAAFSGG DGGKVGGSWG RSIINLAPYA
APGAKVKLRF ELGNDCGGGA LGWYVDDVSV YSCTTP
//
