ID A0A3N7HNX6_9BURK Unreviewed; 303 AA.
AC A0A3N7HNX6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Signal peptidase I {ECO:0000256|ARBA:ARBA00019232, ECO:0000256|RuleBase:RU362042};
DE EC=3.4.21.89 {ECO:0000256|ARBA:ARBA00013208, ECO:0000256|RuleBase:RU362042};
GN Name=lepB {ECO:0000313|EMBL:RQP22411.1};
GN ORFNames=DZC73_22455 {ECO:0000313|EMBL:RQP22411.1};
OS Albitalea terrae.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Albitalea.
OX NCBI_TaxID=2496871 {ECO:0000313|EMBL:RQP22411.1, ECO:0000313|Proteomes:UP000267464};
RN [1] {ECO:0000313|EMBL:RQP22411.1, ECO:0000313|Proteomes:UP000267464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S-16 {ECO:0000313|EMBL:RQP22411.1,
RC ECO:0000313|Proteomes:UP000267464};
RA Khan S.A., Jeon C.O., Chun B.H., Jeong S.E.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:RQP22411.1, ECO:0000313|Proteomes:UP000267464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S-16 {ECO:0000313|EMBL:RQP22411.1,
RC ECO:0000313|Proteomes:UP000267464};
RA Shunsuke S.S.;
RT "Rhizobacter gummiphilus sp. nov., a rubber-degrading bacterium isolated
RT from the soil of a botanical garden in Japan.";
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Cleavage of hydrophobic, N-terminal signal or leader sequences
CC from secreted and periplasmic proteins.; EC=3.4.21.89;
CC Evidence={ECO:0000256|ARBA:ARBA00000677,
CC ECO:0000256|RuleBase:RU362042};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362042}; Single-
CC pass type II membrane protein {ECO:0000256|RuleBase:RU362042}.
CC -!- SIMILARITY: Belongs to the peptidase S26 family.
CC {ECO:0000256|ARBA:ARBA00009370, ECO:0000256|RuleBase:RU362042}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362042}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RQP22411.1}.
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DR EMBL; QUSW01000007; RQP22411.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3N7HNX6; -.
DR Proteomes; UP000267464; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR CDD; cd06530; S26_SPase_I; 1.
DR Gene3D; 2.10.109.10; Umud Fragment, subunit A; 1.
DR InterPro; IPR036286; LexA/Signal_pep-like_sf.
DR InterPro; IPR000223; Pept_S26A_signal_pept_1.
DR InterPro; IPR019758; Pept_S26A_signal_pept_1_CS.
DR InterPro; IPR019757; Pept_S26A_signal_pept_1_Lys-AS.
DR InterPro; IPR019533; Peptidase_S26.
DR NCBIfam; TIGR02227; sigpep_I_bact; 1.
DR PANTHER; PTHR43390:SF1; CHLOROPLAST PROCESSING PEPTIDASE; 1.
DR PANTHER; PTHR43390; SIGNAL PEPTIDASE I; 1.
DR Pfam; PF10502; Peptidase_S26; 1.
DR PRINTS; PR00727; LEADERPTASE.
DR SUPFAM; SSF51306; LexA/Signal peptidase; 1.
DR PROSITE; PS00760; SPASE_I_2; 1.
DR PROSITE; PS00761; SPASE_I_3; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU362042, ECO:0000313|EMBL:RQP22411.1};
KW Membrane {ECO:0000256|RuleBase:RU362042};
KW Protease {ECO:0000256|RuleBase:RU362042};
KW Reference proteome {ECO:0000313|Proteomes:UP000267464};
KW Transmembrane {ECO:0000256|RuleBase:RU362042};
KW Transmembrane helix {ECO:0000256|RuleBase:RU362042}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362042"
FT TRANSMEM 32..51
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362042"
FT TRANSMEM 57..75
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362042"
FT TRANSMEM 87..110
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362042"
FT DOMAIN 94..300
FT /note="Peptidase S26"
FT /evidence="ECO:0000259|Pfam:PF10502"
FT ACT_SITE 120
FT /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
FT ACT_SITE 177
FT /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
SQ SEQUENCE 303 AA; 33935 MW; 73C1F035EAEE779F CRC64;
MHTQPRKWLA VLLCFIFTPI AMLYVGRARW AAVYLLAALG LLAFLLVSPA SPWVTDVLSL
VYFVGGAIHA YWLAAKSESQ QPRRWFSRWY GVMGAIACLV VASLTVRSFF FEPFRQPSQS
MRPTLPMGAT LVVQKWGYGN YGTFGVHGVR RPVSALLERG DILVFEYPKD RAVHFVKRLV
GLPGDKVTYK AKMLFVNDMP AEQHFVRDEL DAETLGSGAV HTESLMGREY SILLDKARID
PGVGHLDFPM HEQCTSNQGE LSCRVPAGHF FVLGDNRDNS ADSRFWGFVP MDHITGKVVL
VKP
//
