ID A0A3N8N740_9BURK Unreviewed; 1966 AA.
AC A0A3N8N740;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156};
GN Name=uvrA {ECO:0000313|EMBL:RQS76982.1};
GN ORFNames=DID96_01525 {ECO:0000313|EMBL:RQS76982.1};
OS Burkholderia sp. Bp8963.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia.
OX NCBI_TaxID=2184547 {ECO:0000313|EMBL:RQS76982.1, ECO:0000313|Proteomes:UP000274808};
RN [1] {ECO:0000313|EMBL:RQS76982.1, ECO:0000313|Proteomes:UP000274808}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bp8963 {ECO:0000313|EMBL:RQS76982.1,
RC ECO:0000313|Proteomes:UP000274808};
RA Hall C., Sahl J., Wagner D.;
RT "Comparative analysis of Burkholderia isolates from Puerto Rico.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000256|ARBA:ARBA00038000}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RQS76982.1}.
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DR EMBL; QTQP01000001; RQS76982.1; -; Genomic_DNA.
DR OrthoDB; 9809851at2; -.
DR Proteomes; UP000274808; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-KW.
DR Gene3D; 3.30.190.20; -; 1.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 3.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR NCBIfam; TIGR00630; uvra; 1.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR PANTHER; PTHR43152:SF3; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 3.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000274808};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SOS response {ECO:0000256|ARBA:ARBA00023236};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 1..615
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1015..1537
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1328..1361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1943..1966
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1328..1344
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1947..1966
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1966 AA; 213809 MW; 6DBB57CC5CBAAB2F CRC64;
MSSSNLIRIR GARQHNLKHI DLDLRTGEMT VVTGPSGSGK SSLVFDTLYA EGQRRYVETF
SAYARQFLDR MDRPQVDRVD GVPPAIAIDQ TNPVRSSRST VGTMTELNDH LKLLYARAAE
LFDCKTAQPV RHDTPETIYA DLSARTTDHD PRLVVTFPVE LPETVTDEEV EQWLSASGYT
RVQARREIAS PTGPRKVLDV VADRFRLHQV DKVRAIEAIE ASLKRGGGRV NVYVLAQAPD
NATDAAAEPQ VWRFSTGLHS PDSDLRYADP QAALFSFNSA YGACETCRGF GRVIGVDLGL
VIPDERKTLR GGAIKPMQTP AWKECQDDLM RYAAKANIRR DTPWADLTSD ERDWVINGSP
DWNGKWQSQW YGVKRFFAYL ESKAYKMHIR VLLSKYRSYT PCDVCGGARL KTESLLWRLG
TKANADAALA PAGRFLPRGV DWTRAQLEAL PGLTVHDLML LPIERIRRFF DDISLPSALL
DDALKLLLAE VRTRLKYLCD VGLGYLTLDR QSRTLSGGEV QRINLTTALG TSLTKTLFVL
DEPSIGLHPR DLNRIVEAMQ RLRDAGNTLV VVEHDPSVML AADRLIDMGP GPGERGGTIV
YDGTPGAIRS ARTLTGEYLG GRKHVAHASH WARRAVDAHT PRIVLESASE HNLRDVTVEI
PLQRLVCVTG VSGSGKSTLL QDVLYPAMAR HLGKATESPG AYRSLTGAEQ VTDVVFVDQS
PIGKTTRSNP ASYVGAFDEI RKLFATAPLA LQRGYSAGTF SFNSGDGRCP TCGGSGFEHI
EMQFLSDVYL RCPDCDGQRY RAEVLEVRIK RDGRALNVAE VLDLTVSEAA AFFAADAEVL
RVLQPIVDVG LEYVKLGQPV PTLSGGEAQR LKLAGFLAES AKAASGRRVV TREARVARLF
MFDEPTTGLH FDDIAKLMQA FGKLLASGHS LIVIEHNLDV IRAADWLIDL GPEGGDGGGL
VLCAGTPDDV KACAESHTGV ALLHYDRAMA ADIEPAEEGV PLQAALSAAR ARREVEGEDI
VRIVNAREHN LKALDVDIPH GKFNVVTGVS GSGKSTLAFD ILFHEGQRRY LESLNAYARS
IVQPAGRPEV DAVYGIPPTV AIEQRLSRGG RKSTVATTSE VWHFLRLLYV KLGLQHCIHD
GTPVTSQSVE SIAAQLLRDH RGDHVGLLAP LVVNRKGVYT DLAKWAKARG STHLRVDGEF
VTVDPWPKLD RFREHTIELP VADIVVSPDH EAELRQRLNE TLELGKGVMH LLAPLDGLHH
AMANDHSTAR IGEVKVLSVK RACPECGTSY PELDPRMFSY NSKHGWCTTC VGTGVTLTRE
QRAAYDDTVL AEDGRGREQT LPSDEQEPEG VGDEPCPDCG GTRLNPSARA VTFEGHPIVD
VAQWTVSDTR RWIDGLQLAG RDAQIARDIV SEIGSRLAFL EEVGLGYLSL DRAAPSLSGG
EAQRIRLAAQ LGSNLQGVCY VLDEPTIGLH PRDNQILLNA LRKLGDKGNT LVVVEHDEDT
IRRADHIIDV GPGAGKRGGT LVAQGGVADL AAQPDSLTGR FLAQPIVHPL QPRRSVNLPG
AKDGAAVPET WLTVHGGKLH NLRDVTVGIP LGRLVAVTGV SGSGKSTLAR DVLMTNLLDA
VGRSVLSSPA TRRARKAAEQ AAPQAANRRA SVLARSAPRP SLNVTHAWQG CESISGWEHI
DRVLEVDQTP IGKTPRSCPA TYIGVWDAIR KLFADTLEAR ARGYTASRFS FNTGDGRCPA
CEGQGVRTIG MSFLPDVKVP CDVCHGQRFN PETLAVTWRG RNIGDVLTME IDEAVEFFAP
ISNIAHPLQL MKDVGLGYLT LGQPSPTLSG GEAQRIKLVT ELSKVRDDIT RRGQKAPHTL
YVLDEPTVGL HMADVAKLIH VLHRLVDAGH SVVVIEHDLD VIAEADWIID LGPEGGVGGG
AIVAAAHPEG LVQVSASHTG RALEPVLARS RADRGEHGRR GEAGVG
//
