ID   A0A3P0XAB3_9BACT        Unreviewed;       674 AA.
AC   A0A3P0XAB3;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=Squalene--hopene cyclase {ECO:0000313|EMBL:RRA49460.1};
DE            EC=5.4.99.17 {ECO:0000313|EMBL:RRA49460.1};
GN   Name=shc {ECO:0000313|EMBL:RRA49460.1};
GN   ORFNames=D1Y84_15420 {ECO:0000313|EMBL:RRA49460.1};
OS   Acidipila sp. EB88.
OC   Bacteria; Acidobacteriota; Terriglobia; Terriglobales; Acidobacteriaceae;
OC   Acidipila.
OX   NCBI_TaxID=2305226 {ECO:0000313|EMBL:RRA49460.1, ECO:0000313|Proteomes:UP000279598};
RN   [1] {ECO:0000313|EMBL:RRA49460.1, ECO:0000313|Proteomes:UP000279598}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EB88 {ECO:0000313|EMBL:RRA49460.1,
RC   ECO:0000313|Proteomes:UP000279598};
RA   Pold G., Deangelis K.;
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:RRA49460.1, ECO:0000313|Proteomes:UP000279598}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EB88 {ECO:0000313|EMBL:RRA49460.1,
RC   ECO:0000313|Proteomes:UP000279598};
RA   Horta L.;
RT   "Genome sequence of EB88, a novel member of the group I Acidobacteria.";
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004999}.
CC   -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC       {ECO:0000256|ARBA:ARBA00009755}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RRA49460.1}.
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DR   EMBL; QWEV01000005; RRA49460.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3P0XAB3; -.
DR   OrthoDB; 9758578at2; -.
DR   UniPathway; UPA00337; -.
DR   Proteomes; UP000279598; Unassembled WGS sequence.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0051007; F:squalene-hopene cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd02892; SQCY_1; 1.
DR   Gene3D; 1.50.10.20; -; 2.
DR   InterPro; IPR006400; Hopene-cyclase.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR002365; Terpene_synthase_CS.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   NCBIfam; TIGR01507; hopene_cyclase; 1.
DR   NCBIfam; TIGR01787; squalene_cyclas; 1.
DR   PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR   PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR   PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000313|EMBL:RRA49460.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000279598};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          34..321
FT                   /note="Squalene cyclase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13249"
FT   DOMAIN          340..667
FT                   /note="Squalene cyclase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
SQ   SEQUENCE   674 AA;  76930 MW;  DC83E43A8064DD4F CRC64;
     MSTAPQQEQL GNQGSRLRFG RLDVALDSVE SAIGRVRDWL FSQQHPDGYW CGELEADSLL
     EADYIFGHML LGTGDPARLE RALAEMMRTQ GEDGSWANYP GGPGNISVSV KCYFACKLMG
     WSQDEPRLVR AREWILANGG VVECNTFTKI YLCFMGQYEY DAVPAVPPEI VLFPNWFYFN
     IYEISSWSRA ILVPLSIAYA KKPFKKIAPE QGIDELFVGG RENANLHLRW DREKPVSWRN
     FFLLTDRLTH WAERVHIRPL RRMALKRAEK WMLARLELSD GLGAIYPAIL NSMIALRWLG
     YSIDDPQMIR ASDEFEKLGI DAPEGTADYA EPTFRMQPCV SPVWDTAQAV FALGEAGVER
     TDPRMLKAVD WMLSKEVRHK GDWAEKVRNT EPGGWYFEFA NEWYPDVDDT AQVLLALNKV
     DNPRERYQYD VSKRALDWIF AMQCRNGGWA SFDKDNTKMI FQYIPFADHN AMLDPPTVDI
     TGRVLETLST YGYTRSDKRI ERAIKFIFDE QESDGSWFGR WGVNYLYGTF LVLRGLEAIG
     IWNHEPQIQQ AAEWIRMVQN ADGGWGESCL SYDEPDLRGV GASTPSQTAW AVLGLLSAGD
     KRSDSVAKGV RWLLEHQAES GGWDESTDAA TQKQAVYTGT GFPRVFYLAY HLYRDYFPLL
     ALTTYKRAIE RGDE
//