ID A0A3P1WJB5_9ACTN Unreviewed; 516 AA.
AC A0A3P1WJB5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase {ECO:0000313|EMBL:RRD45818.1};
GN ORFNames=EII42_09770 {ECO:0000313|EMBL:RRD45818.1};
OS Tessaracoccus sp. OH4464_COT-324.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Tessaracoccus.
OX NCBI_TaxID=2491059 {ECO:0000313|EMBL:RRD45818.1, ECO:0000313|Proteomes:UP000274803};
RN [1] {ECO:0000313|EMBL:RRD45818.1, ECO:0000313|Proteomes:UP000274803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OH4464_COT-324 {ECO:0000313|EMBL:RRD45818.1,
RC ECO:0000313|Proteomes:UP000274803};
RA Coil D.A., Jospin G., Darling A.E., Wallis C., Davis I.J., Harris S.,
RA Eisen J.A., Holcombe L.J., O'Flynn C.;
RT "Genomes From Bacteria Associated with the Canine Oral Cavity: a Test Case
RT for Automated Genome-Based Taxonomic Assignment.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RRD45818.1}.
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DR EMBL; RQYZ01000019; RRD45818.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3P1WJB5; -.
DR OrthoDB; 9815856at2; -.
DR Proteomes; UP000274803; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR039793; UROS/Hem4.
DR PANTHER; PTHR40082; BLR5956 PROTEIN; 1.
DR PANTHER; PTHR40082:SF1; BLR5956 PROTEIN; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000313|EMBL:RRD45818.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000274803};
KW Transferase {ECO:0000313|EMBL:RRD45818.1}.
FT DOMAIN 9..196
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 246..476
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
FT REGION 491..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 516 AA; 55341 MW; 2443E55F93A2CE8D CRC64;
MAEVGLGSVT FVGSGPGEFG LLTLLGARSL RFADLVVIDQ RVDIDEVRKL TAGHTRIELV
AEDEVAQLVE AAREGLKTVR LSQDDHFCEA FTTDVVPRVR AAGVRINVIP GLNRWSTLFT
YGAIATGRTT AYMHACDHAP EIEQWPTAGT VALHTSGSLL GEIGRVAQER YAPNDKVLLL
SGVGSTAQTS RMLTWADLAP IDEGECYIVY GDAIADSDRA RVGWYESKPL FDWRVLSPRT
KDDLGRLAEE LAQYGATTET IPTMSIEPPR TEQGMERAVR GLVDGRYLWC VFTSPHAVAA
VAERLAEYGL DSRALSGISI AAVGRGTAGE LRKLGIVADL EPSGPNTVGA LATEFPAFDN
MMDPMNRVLV PSADVSIEPL MEGLGHLGWE VEGVTAYRTV RAAPPPAETR EAIKGGMFDA
VVFTSATAVR NMIGIAGKPH AVSIIAAIGE ATAAACEQHG LRVDVIAKSP TFASLAEGLA
QFADERRAAA LAKGEPLKKP SERKRRRRRK TVAEAT
//
