ID   A0A3P1WQB3_9ACTN        Unreviewed;       999 AA.
AC   A0A3P1WQB3;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=ExeM/NucH family extracellular endonuclease {ECO:0000313|EMBL:RRD46703.1};
GN   ORFNames=EII42_05610 {ECO:0000313|EMBL:RRD46703.1};
OS   Tessaracoccus sp. OH4464_COT-324.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Propionibacteriaceae; Tessaracoccus.
OX   NCBI_TaxID=2491059 {ECO:0000313|EMBL:RRD46703.1, ECO:0000313|Proteomes:UP000274803};
RN   [1] {ECO:0000313|EMBL:RRD46703.1, ECO:0000313|Proteomes:UP000274803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OH4464_COT-324 {ECO:0000313|EMBL:RRD46703.1,
RC   ECO:0000313|Proteomes:UP000274803};
RA   Coil D.A., Jospin G., Darling A.E., Wallis C., Davis I.J., Harris S.,
RA   Eisen J.A., Holcombe L.J., O'Flynn C.;
RT   "Genomes From Bacteria Associated with the Canine Oral Cavity: a Test Case
RT   for Automated Genome-Based Taxonomic Assignment.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RRD46703.1}.
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DR   EMBL; RQYZ01000007; RRD46703.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3P1WQB3; -.
DR   OrthoDB; 1016457at2; -.
DR   Proteomes; UP000274803; Unassembled WGS sequence.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   CDD; cd10283; MnuA_DNase1-like; 1.
DR   CDD; cd04486; YhcR_OBF_like; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR047971; ExeM-like.
DR   InterPro; IPR001322; Lamin_tail_dom.
DR   NCBIfam; NF033681; ExeM_NucH_DNase; 1.
DR   PANTHER; PTHR42834; ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09210); 1.
DR   PANTHER; PTHR42834:SF1; ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09210); 1.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   Pfam; PF00932; LTD; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   PROSITE; PS51841; LTD; 1.
PE   4: Predicted;
KW   Endonuclease {ECO:0000313|EMBL:RRD46703.1};
KW   Hydrolase {ECO:0000313|EMBL:RRD46703.1};
KW   Nuclease {ECO:0000313|EMBL:RRD46703.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274803};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..999
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018271179"
FT   DOMAIN          20..139
FT                   /note="LTD"
FT                   /evidence="ECO:0000259|PROSITE:PS51841"
FT   REGION          188..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          776..843
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          969..999
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        192..213
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        787..825
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   999 AA;  105035 MW;  724D12C49D7C0733 CRC64;
     MRFTRRVWAG AVVTSLVAAT WYAAPLASAT AADLIISEYV EGPSNEKAIE LYNGTGAAVS
     LDGYKLSLYT NGATTARNNE MLTGSLAAGA AYVIRHKDAK QLPQGNLVSS VTNFNGDDAL
     VLYKGDTVVD SIGTVGSKDK WGQDKTLTRK PDVTAGDKIV GDAFDPAVQW KVEANSSTVH
     HTLGTHVMEG GGPVPPPAPP TPSVSPTPSV TPTPKPGGTC QVAGKKIGEI QGTGDESPLV
     GHTVEMIGTV VGDFQEGGFK GFYLQDAGDG DPATSDGIFV YDGKSKAGDV QVGDVVYVKG
     GVKENYGMTQ VTLVEAEKCA TAALPEPTIV DFPNTGFEKF EGMLVSFAKP LTVLETYQYG
     RYGQIAVGPE RQFQPSAVHA PDSAEARALL ASNAANRVLI DDGRSAQNAS PALHPASLRP
     LTAETTFRGG DQISSLAGVL DYRFNNWAVQ PVKPGQIKAV NPRAGRPDVG GDLKVASFNV
     LNYFTTLKSE DPNARGADNA EEFQRQEAKI VAAINKVDGA IMGLNEVENN ATALESLVAA
     LNKAAGSAKW AALKTGRIGS DAITTAFIYQ PALVELVGDF DTLTKADDPE FNDGKNRPTL
     AQTFKHKASG ETITVAVNHL KSKGSACGDP SEATMQPIVG NCNETRTKAA KAMAKWLKGS
     SIGVTKSENI LIMGDLNSYD HESPIGELID AGFADQIKRF GGEFAYSYVF NGQLGYLDHA
     LANPALASRI VGAAEWNINS DEMSLIDYDT SFKKPAEQAL YRADEFRSSD HDPVIVGIQF
     GKKPSPEPSV TPSPEPSVTP SPEPSVTPSP EPSVTPSPAP SVTPTGSPSV TPTASPSAPL
     PELPLANDAD AKACVESGGV YVVVDGFEGS KVWGGCARQF GDAVEALRSA GFSPELRAAG
     PFRSKGMVVV GINGRKAADG ASWNVFGKSI DTAKQQWNPW SPWSQKRAVK AGTVLGWALG
     KSMEVAPRWD GYKLGSKPSG KQPKPKPGKP RPGLPKTGS
//