ID A0A3P1XPH7_9MICO Unreviewed; 362 AA.
AC A0A3P1XPH7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=EII30_05240 {ECO:0000313|EMBL:RRD60659.1};
OS Leucobacter sp. OH1287.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Leucobacter.
OX NCBI_TaxID=2491049 {ECO:0000313|EMBL:RRD60659.1, ECO:0000313|Proteomes:UP000281351};
RN [1] {ECO:0000313|EMBL:RRD60659.1, ECO:0000313|Proteomes:UP000281351}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OH1287 {ECO:0000313|EMBL:RRD60659.1,
RC ECO:0000313|Proteomes:UP000281351};
RA Coil D.A., Jospin G., Darling A.E., Wallis C., Davis I.J., Harris S.,
RA Eisen J.A., Holcombe L.J., O'Flynn C.;
RT "Genomes From Bacteria Associated with the Canine Oral Cavity: a Test Case
RT for Automated Genome-Based Taxonomic Assignment.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RRD60659.1}.
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DR EMBL; RQYM01000007; RRD60659.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3P1XPH7; -.
DR Proteomes; UP000281351; Unassembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Isomerase {ECO:0000313|EMBL:RRD60659.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000281351}.
FT DOMAIN 13..360
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 362 AA; 38343 MW; 5C0EB4AF51274CB7 CRC64;
MSIAVTKILG GTRITLARPE KLNALTLSMC QEIARAVAEA SAAAEAAELA GATGAAGADP
TAAIVIDGEG DRGFCAGGDV RQICDSPEAT AEFLTAEYAM DLAVAKNPAV ITVMHGITMG
GGVGVGCHAG KRFVTETLRL AMPETKIGSV PDVGGTLLLA RTPSQLGELL GVTGTAITAG
DALALGFADH FLPEEVRKHL TEHPDQLVGE LSRRAADPHP NPKQPESQLL AELEWLDPLL
TKALGDSADP RGLAVEYPEV ALRQLESELR AEPRAARFAQ DLAQASPLAA AVTLQRIAVQ
RRNPQPLEAV LAEDFRVFNL FAKTPDFQAG VTARLITKTG DPQWQTAKTE QLQRQQIARF
ER
//
