ID A0A3P1Y2F6_9BACT Unreviewed; 590 AA.
AC A0A3P1Y2F6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=2-oxoacid:acceptor oxidoreductase subunit alpha {ECO:0000313|EMBL:RRD65011.1};
GN ORFNames=EII26_04830 {ECO:0000313|EMBL:RRD65011.1};
OS Fretibacterium sp. OH1220_COT-178.
OC Bacteria; Synergistota; Synergistia; Synergistales; Aminobacteriaceae;
OC Fretibacterium.
OX NCBI_TaxID=2491047 {ECO:0000313|EMBL:RRD65011.1, ECO:0000313|Proteomes:UP000267192};
RN [1] {ECO:0000313|EMBL:RRD65011.1, ECO:0000313|Proteomes:UP000267192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OH1220_COT-178 {ECO:0000313|EMBL:RRD65011.1,
RC ECO:0000313|Proteomes:UP000267192};
RA Coil D.A., Jospin G., Darling A.E., Wallis C., Davis I.J., Harris S.,
RA Eisen J.A., Holcombe L.J., O'Flynn C.;
RT "Genomes From Bacteria Associated with the Canine Oral Cavity: a Test Case
RT for Automated Genome-Based Taxonomic Assignment.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RRD65011.1}.
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DR EMBL; RQYL01000008; RRD65011.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3P1Y2F6; -.
DR Proteomes; UP000267192; Unassembled WGS sequence.
DR GO; GO:0016903; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors; IEA:InterPro.
DR CDD; cd07034; TPP_PYR_PFOR_IOR-alpha_like; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR Gene3D; 3.40.920.10; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
DR InterPro; IPR022367; 2-oxoacid/accept_OxRdtase_asu.
DR InterPro; IPR019752; Pyrv/ketoisovalerate_OxRed_cat.
DR InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR InterPro; IPR002869; Pyrv_flavodox_OxRed_cen.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR NCBIfam; TIGR03710; OAFO_sf; 1.
DR PANTHER; PTHR32154:SF20; 2-OXOGLUTARATE OXIDOREDUCTASE SUBUNIT KORA; 1.
DR PANTHER; PTHR32154; PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED; 1.
DR Pfam; PF01558; POR; 1.
DR Pfam; PF01855; POR_N; 1.
DR SUPFAM; SSF53323; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000267192}.
FT DOMAIN 25..187
FT /note="Pyruvate/ketoisovalerate oxidoreductase catalytic"
FT /evidence="ECO:0000259|Pfam:PF01558"
FT DOMAIN 224..450
FT /note="Pyruvate flavodoxin/ferredoxin oxidoreductase
FT pyrimidine binding"
FT /evidence="ECO:0000259|Pfam:PF01855"
SQ SEQUENCE 590 AA; 62775 MW; F08DBC2F793EE828 CRC64;
MPVTNEKTRN GESRRDFCLR LCAAAGQGLQ TMEDMLCQLL TDAGYHLFST REYMSRVRGG
NNSTSIRVST RPVRAWSERI DLLFVLAEGV RPNVLSRVTP ETTVVADLAR LEADAAKLRE
TGASLVDLPL AAKAKELGGA IYEATLVGGL VAGVLGLLPE SADPLYEARF KVAEVAARNK
EAFRRGHALG VELRDAHPRF ALNPPSSASS ARMLMSGNLS VAVGCAAAGC NFVSAYPMSP
GTALFSFFSK NAGLFDCAVE QAEDEIAAIN MAIGASYAGA RTLVSTSGGG FALMGEGLSL
AGITETPVVV HLAQRPGPAT GMATRTEQAD LNLALYAGHG DFPRALLAPG SAESAPEIAA
RAFAIAAKFQ TPVILLTDQH FLDSAYDLAP PDPGVLPQPE GPVRTAAGYA RYALSDSPLS
PRGVPGHGEG LVGFDSHEHT EDAHITEDFA LRVRMNDKRM AKLERMRDEA MPPTVVGPRG
AKILVVCWGS LAEPLKEAFA VLDPDDAALV CCEQVYPLSR EMDALMRSAE RRIFVENNAA
GQFARLVHLE TGFAATDTVL KYDGQPFSVE ELTGRLGELL GRHSQKGAGR
//
