ID A0A3P2A0U0_9BACE Unreviewed; 727 AA.
AC A0A3P2A0U0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=recQ {ECO:0000313|EMBL:RRD89032.1};
GN Synonyms=recQ_3 {ECO:0000313|EMBL:VFB14335.1};
GN ORFNames=EII33_10775 {ECO:0000313|EMBL:RRD89032.1}, NCTC7812_01884
GN {ECO:0000313|EMBL:VFB14335.1};
OS Bacteroides heparinolyticus.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=28113 {ECO:0000313|EMBL:RRD89032.1, ECO:0000313|Proteomes:UP000279562};
RN [1] {ECO:0000313|EMBL:RRD89032.1, ECO:0000313|Proteomes:UP000279562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OH1047_COT-310 {ECO:0000313|EMBL:RRD89032.1,
RC ECO:0000313|Proteomes:UP000279562};
RA Coil D.A., Jospin G., Darling A.E., Wallis C., Davis I.J., Harris S.,
RA Eisen J.A., Holcombe L.J., O'Flynn C.;
RT "Genomes From Bacteria Associated with the Canine Oral Cavity: a Test Case
RT for Automated Genome-Based Taxonomic Assignment.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:VFB14335.1, ECO:0000313|Proteomes:UP000396835}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3012STDY7078512 {ECO:0000313|EMBL:VFB14335.1,
RC ECO:0000313|Proteomes:UP000396835};
RG Pathogen Informatics;
RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
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DR EMBL; RQYF01000061; RRD89032.1; -; Genomic_DNA.
DR EMBL; CAACYH010000004; VFB14335.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3P2A0U0; -.
DR OrthoDB; 9763310at2; -.
DR Proteomes; UP000279562; Unassembled WGS sequence.
DR Proteomes; UP000396835; Unassembled WGS sequence.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:InterPro.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 1.10.10.1390; ATP-dependent DNA helicase RecQ; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR006293; DNA_helicase_ATP-dep_RecQ_bac.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR048671; RecQ-1-like_HTH.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR01389; recQ; 1.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF105; BLOOM SYNDROME PROTEIN; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF21220; RecQ-1-like_HTH; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:RRD89032.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:RRD89032.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000279562}.
FT DOMAIN 29..200
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 222..373
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 530..610
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
SQ SEQUENCE 727 AA; 82009 MW; 0FF2912D993C729D CRC64;
MAGKKTNLTD QLKKYFGFDA FKGNQEAIME NLLAGNDTFV LMPTGGGKSL CYQLPSLLME
GTAIVISPLI ALMKNQVDAM RNFSEEDGVA HFINSSLNKS AIDQVKADIL GGKTKLLYVA
PESLTKEENV EFLKTVKISF YAVDEAHCIS EWGHDFRPEY RRIRPIINEI GKAPLIALTA
TATPKVQHDI QKNLGMVEAQ VFKSSFNRPN LYYEVRSKTA NVDKDIIKFI KNNPEKSGII
YCLSRKKVEE LAEILQANGI NARAYHAGMD SATRTQNQDD FLMEKTDVIV ATIAFGMGID
KPDVRYVIHY DIPKSLEGYY QETGRAGRDG GEGQCITFYT NKDLQKLEKF MQGKPVAEQE
IGRQLLLETA AYAESSVCRR KALLHYFGEE YTEDNCGNCD NCLNPKKQVE AQELLCTVIE
TVLSVKENFK ADYIIDVIQG RETSEVQAHL HEELEVFGSG MGEEDKTWNA VIRQALIAGY
LSKDVENYGL LKVTEDGKKF LKHPKSFKIV EDNDFEEAEE EAPARGGGTC AVDPTLYSML
KDLRKKLSKK LEVPPYVIFQ DPSLEAMATI YPVTLDELQN IPGVGAGKAK RYGEEFCKLI
KRHCEENEIE RPEDLRVRTV ANKSKMKVAI IQAIDRKVAL DDIAMSKGIE FEELLDEIEA
IVYSGTKLNI DYFLEDIMDE DHMLDIYDYF KESTTDKIDD ALDELGDDFT EEEVRLVRIK
FISEMAN
//
