ID   A0A3P3VWA5_9MICO        Unreviewed;       713 AA.
AC   A0A3P3VWA5;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=MMPL family transporter {ECO:0000313|EMBL:RRJ87082.1};
GN   ORFNames=EG850_06030 {ECO:0000313|EMBL:RRJ87082.1};
OS   Gulosibacter macacae.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Gulosibacter.
OX   NCBI_TaxID=2488791 {ECO:0000313|EMBL:RRJ87082.1, ECO:0000313|Proteomes:UP000274391};
RN   [1] {ECO:0000313|EMBL:RRJ87082.1, ECO:0000313|Proteomes:UP000274391}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YIM 102482-1 {ECO:0000313|EMBL:RRJ87082.1,
RC   ECO:0000313|Proteomes:UP000274391};
RA   Li G., Jiang Y.;
RT   "YIM 102482-1 draft genome.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RRJ87082.1}.
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DR   EMBL; RQVS01000006; RRJ87082.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3P3VWA5; -.
DR   OrthoDB; 2365435at2; -.
DR   Proteomes; UP000274391; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274391};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        173..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        198..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        231..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        306..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        371..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        541..558
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        565..589
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        601..618
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        639..665
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        671..695
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          568..696
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   713 AA;  75265 MW;  035174F8C0A61A08 CRC64;
     MRRGGPGWAK WLRILIPALL IVAWLVGAGQ GGPLFSKVSE VAVNDQTLYL PESADATAVQ
     EQLGSFLGED AIPAIIVWSS PDALTDADFT AINEALTAIT DINHVLETSP VIPSEDGLAA
     QAFVALDSSV LPGETVPELR DVLAETPNDL TVQVTGPAGF TADLSASFAG IDGLLLLVAL
     GVVLVILIIV YRSPMLPFIV LATSLFALCT ALLLVWWLAK WEILLLSSQT QGILFILVIG
     AATDYSLLYV ARYRETLREH ESKWDATWAA LRGTWEPVLA SGGTVIAGLL MLLFSDLKTN
     STLGPVAAIG IVFSMLAALT LLPALLFWAG RAAFWPRRAK FDASWSAEDE AIHGNGFWPR
     LARWVQRAPR AIWISTTIIL AVLAAFSLQL KAEGVPASEF VLGESEARDG QAALGEHFPG
     GSGSPAYVIV PEAELQQTAT ALLGLEGISS VAVTASDSAA GTAPVTEDGI QAFGPPGTPA
     PAPTVVDGKV LLQATLTDAA DSDAAQATVI EIREQLPESL VGGVTATALD TNTTSVNDRN
     LIIPLVLLVI TLILMLLLRS IVAPLLLVVT TVLSFGTAMG VAALLFNYVF DFPGADPSVP
     LYGFVFLVAL GIDYNIFLMT RVREESLVHG TREGVQRGLA VTGGVITSAG IVLAATFAAL
     AVLPIMFLAQ LAFIVAFGVL LDTFIVRSLL VPALVTDIGR KVWWPSKLAV GEE
//