ID   A0A3P4B3L0_9BURK        Unreviewed;      1033 AA.
AC   A0A3P4B3L0;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Cobalt-zinc-cadmium resistance protein CzcA {ECO:0000313|EMBL:VCU70208.1};
GN   Name=czcA_2 {ECO:0000313|EMBL:VCU70208.1};
GN   ORFNames=PIGHUM_02275 {ECO:0000313|EMBL:VCU70208.1};
OS   Pigmentiphaga humi.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Pigmentiphaga.
OX   NCBI_TaxID=2478468 {ECO:0000313|EMBL:VCU70208.1, ECO:0000313|Proteomes:UP000277294};
RN   [1] {ECO:0000313|EMBL:VCU70208.1, ECO:0000313|Proteomes:UP000277294}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DnA1 {ECO:0000313|EMBL:VCU70208.1};
RA   Criscuolo A.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
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DR   EMBL; UWPJ01000017; VCU70208.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3P4B3L0; -.
DR   OrthoDB; 9798415at2; -.
DR   Proteomes; UP000277294; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR004763; CusA-like.
DR   NCBIfam; TIGR00914; 2A0601; 1.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF24; CATION EFFLUX SYSTEM (ACRB_ACRD_ACRF FAMILY); 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000277294}.
SQ   SEQUENCE   1033 AA;  111710 MW;  A56C232A445BDCBA CRC64;
     MLEKIVRAAL QQRLIVVVLA VVALVVGLDA MRKLSVDAFP DVTNVQVQIA TDATGRSPEE
     VERFVTVPIE IAMTGLPGLE EMRSLNKPGL SLITLVFTDA TDVYFARQLV MERLIEIGSR
     MPGGVTPVLG PVSTGLGEVY QYTLDRLDDG DRELTQQELT ERRIVQDWVV RPLLRSIPQV
     AEINSQGGYV KQYQVLVNPD RMSHYGISLQ QVYQGLARNN ANSGGGVLPH YAEQYLIRGV
     GLIESLDDIA NIVLAESGGT PVYVRDVAEV AMGHEVRYGA VVKNGVTESV GGIVMMMRGG
     NAKEVVARIK QRVAEINGQG MLPGGLQIVP YYDRSELVDA ALWTVAKVLL EGVALVVVVL
     FLFLGDVRSS VIVVATLVLT PLLTFLAMNR LGISANLMSL GGLAVAIGLM VDGSVVVVEN
     AFAHLGHARE TGASKIRIIL KAVAEVATPV VSGIGIIILV FLPLMTLQGM EGKMFAPLAY
     TIAIALAISL VLSMTLSPVL SSYLLKGGAE HDTRLIGFMK RHYLRMLHWA LGNAKKTVLL
     AVTAFALSLA LLPLLGTAFI PEMKEGSIVP GINRVPNISL DESIALEKQA MKIIMGVPGV
     KSAISGVGRG ESPADPQAQN ESTPIVSLKP REEWPDGWTQ DDIAEEIQKR LRVIPSAQVV
     MAQPISDRVD EMVTGVRSDV AVKVFGEDLD RLLHKAQEIA RVAETVQGSR DVRVDRVSGQ
     QYLTINIDRQ AIARYGLNVS DVHDVIEVAI AGKEATDIYE GERRFSAAVR LPESFRGNVP
     AIRQILLTTP EGVRVPLESL ARIDVLDGPA QISREGGKRR VVVAINVQNR DLGGFVAELQ
     QVVQDKVKLP TGYYLEWGGQ FQNMERALGH LSIIVPATVA AIFFVLFLLF NSVRYATLII
     TVLPFASIGG IIGLFVTGEY LSVPASVGFI ALWGIAVLNG VVMVSYIRNL RLEGKALDAA
     VVEGATMRFR PVMMTATVAM LGLVPFLFAT GPGSEVQRPL AVVVIGGLIT CTLLTLLVLP
     TLYRWFDEKT PEA
//