ID A0A3P5W123_9RHOB Unreviewed; 873 AA.
AC A0A3P5W123;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:VDC16926.1};
GN ORFNames=PARPLA_00266 {ECO:0000313|EMBL:VDC16926.1};
OS Rhodobacteraceae bacterium THAF1.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae.
OX NCBI_TaxID=2483814 {ECO:0000313|EMBL:VDC16926.1, ECO:0000313|Proteomes:UP000275054};
RN [1] {ECO:0000313|EMBL:VDC16926.1, ECO:0000313|Proteomes:UP000275054}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATHAF1 {ECO:0000313|EMBL:VDC16926.1};
RA Criscuolo A.;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; UXAS01000011; VDC16926.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3P5W123; -.
DR Proteomes; UP000275054; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000275054}.
FT DOMAIN 700..716
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 626..633
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 873 AA; 93945 MW; D5FFF6667F333E9E CRC64;
MTDQPTPMMA QYLGIKRDHP DALLFYRMGD FYELFFDDAV AAAAALDIAL TKRGKHLGED
IAMCGVPVHS AEGYLLTLIR KGFRVAVCEQ LEDPAEAKKR GAKSVVKRGV VRLVTPGTLT
EESLLDARRH NYLAAWADVR GEGALAWVDI STGEMRVTPC TRVRLGPELA RLAAREVLLS
ETVEGELAPL VTDMGAATTA LSRGSFDSTT GEARLCATWK VGSLDAFGSF ARAEVSAMAA
LVDYLEITQK GKLPLLRPPV REEPSAVMQI DAATRRNLEL THALSGGRTG SLLWAVDRTV
TAPGGRLLER RLTAPSRDLG TIRARQSAVA WFHDDWRACA DLRTALGRVP DMDRALSRLA
LERGGPRDLT AIRDGLSRAA EIADGMRGDL PDLLADALEG CRDHDALIEM LDAALVAEPP
LLVRDGGFIA PGYDTDLDEA RKLRDEGRGV IAAMQAQFAE ETGISALKVK HNNVLGYFIE
VTATHADKMH GLDRFIHRQT TASAVRFTTI ELSELETKIL NAGSRALEIE KTLFASLSQA
VVEAAADVGR AARALAELDV QSALADLARA EDWVRPVVED NRVFDIAGGR HPVVERALKA
QGGGAFIPND CDLSDGSGAA CWLLTGPNMA GKSTFLRQNA VIALLAQMGA FVPADAATIG
VVSQLFSRVG AADDLARGRS TFMVEMVETA AILNQADDAA LVILDEIGRG TATYDGLSIA
WATLEHLHDV NRCRALFATH YHELTRLAEK LDGVRNATVT VKEWEGEVIF LHEVRKGSAD
RSYGVQVAKL AGLPGAVVAR AEVVLAALEK GEAEGKRATL VDDLPLFSAA PTSPAKAKRS
DVEARLAELH PDELTPKAAL ELVYELKGLV KPT
//
