ID A0A3P5WGJ3_9RHOB Unreviewed; 403 AA.
AC A0A3P5WGJ3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Acyltransferase {ECO:0000313|EMBL:VDC20768.1};
DE EC=2.3.1.- {ECO:0000313|EMBL:VDC20768.1};
GN Name=fadA_1 {ECO:0000313|EMBL:VDC20768.1};
GN ORFNames=PARPLA_01157 {ECO:0000313|EMBL:VDC20768.1};
OS Rhodobacteraceae bacterium THAF1.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae.
OX NCBI_TaxID=2483814 {ECO:0000313|EMBL:VDC20768.1, ECO:0000313|Proteomes:UP000275054};
RN [1] {ECO:0000313|EMBL:VDC20768.1, ECO:0000313|Proteomes:UP000275054}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATHAF1 {ECO:0000313|EMBL:VDC20768.1};
RA Criscuolo A.;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR EMBL; UXAS01000018; VDC20768.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3P5WGJ3; -.
DR Proteomes; UP000275054; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00098; THIOLASE_1; 1.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:VDC20768.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000275054};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:VDC20768.1}.
FT DOMAIN 5..229
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 280..402
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 91
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 359
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 389
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 403 AA; 42848 MW; 8DA23F57D6EB1D5E CRC64;
MTDAYIFDAV RTPRGKGRKD GSLHEVTSAR LSAVTLNALK DRNGLDGHFV EDVIWGNATQ
VKEQGGCLAR TAVLASDLDE RIPGLSINRF CASGMEAVNL AANQIKGGAG QAYIAGGVEC
MSRVPMGSDG AAIAVDPSIA MDQYFVPQGI SADIIATEYG FSRDDADALA VESQKRAAKA
WEEGRFDKSI ISVKDRNGLT ILDRDEYLRP GTDMQALGAL NPAFKDQGES MPGFDQLALM
KYPHLEKINH IHHAGNSSGI VDGAAGVLIG SKEWGEANGL KPRARIRATA KVGNDPTIML
IGPVPATDRI LQQSGMTIGD IDLFEVNEAF ASVVLRFMQY FDVDQSRVNV NGGAIAMGHP
LGASGAIIIN TLLDEMERTD KEVGLATLCV ASGMGAATII ERV
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