ID A0A3P5WXU3_9RHOB Unreviewed; 307 AA.
AC A0A3P5WXU3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE SubName: Full=Glyoxylate/hydroxypyruvate reductase B {ECO:0000313|EMBL:VDC20837.1};
DE EC=1.1.1.79 {ECO:0000313|EMBL:VDC20837.1};
GN Name=tkrA_2 {ECO:0000313|EMBL:VDC20837.1};
GN ORFNames=PARPLA_01227 {ECO:0000313|EMBL:VDC20837.1};
OS Rhodobacteraceae bacterium THAF1.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae.
OX NCBI_TaxID=2483814 {ECO:0000313|EMBL:VDC20837.1, ECO:0000313|Proteomes:UP000275054};
RN [1] {ECO:0000313|EMBL:VDC20837.1, ECO:0000313|Proteomes:UP000275054}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATHAF1 {ECO:0000313|EMBL:VDC20837.1};
RA Criscuolo A.;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC ECO:0000256|RuleBase:RU003719}.
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DR EMBL; UXAS01000018; VDC20837.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3P5WXU3; -.
DR Proteomes; UP000275054; Unassembled WGS sequence.
DR GO; GO:0030267; F:glyoxylate reductase (NADP+) activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR CDD; cd12156; HPPR; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996:SF178; 2-HYDROXYACID DEHYDROGENASE YGL185C-RELATED; 1.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719,
KW ECO:0000313|EMBL:VDC20837.1}; Pyruvate {ECO:0000313|EMBL:VDC20837.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000275054}.
FT DOMAIN 41..307
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 103..275
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 307 AA; 32583 MW; 1A6C4A8AC21495B9 CRC64;
MPDIISIGAY PKVDRAALAG MGAVPFATLE EALAMDDRDS VRAIACIAVR LDAATMDAFP
NLGIIANCMV GYDSIDVKAA RERGIAVTNT PDVLNDDVAD LAVALLFAQA RGMVQADAHV
RTGAWATEFF PLNRKVSGGT VGILGLGRIG QEIADRLAAF KMDIHYWSRS EKETPGWTYH
ADPVSLAHAV DFLIVACVGG PETRDIVSSE VIEALGKDGV IVNISRGSTI DEAALLDALE
NGRLAGAGLD VFENEPAPNP RFTKLDNVVL QPHQASATHA TRAAMGQLQR DNIAAFLKGE
PLLTQVN
//
