ID   A0A3P6HJE6_ENTVE        Unreviewed;      1759 AA.
AC   A0A3P6HJE6;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   13-SEP-2023, entry version 18.
DE   RecName: Full=C2 DOCK-type domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=EVEC_LOCUS2283 {ECO:0000313|EMBL:VDD87140.1};
OS   Enterobius vermicularis (Human pinworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Enterobius.
OX   NCBI_TaxID=51028 {ECO:0000313|EMBL:VDD87140.1, ECO:0000313|Proteomes:UP000274131};
RN   [1] {ECO:0000313|EMBL:VDD87140.1, ECO:0000313|Proteomes:UP000274131}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00983}.
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DR   EMBL; UXUI01007351; VDD87140.1; -; Genomic_DNA.
DR   STRING; 51028.A0A3P6HJE6; -.
DR   Proteomes; UP000274131; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 1.20.58.740; -; 1.
DR   Gene3D; 1.25.40.410; -; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   InterPro; IPR027007; C2_DOCK-type_domain.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR026791; DOCK.
DR   InterPro; IPR021816; DOCK_C/D_N.
DR   InterPro; IPR043161; DOCK_C_lobe_A.
DR   InterPro; IPR043162; DOCK_C_lobe_C.
DR   InterPro; IPR027357; DOCKER_dom.
DR   InterPro; IPR046769; DOCKER_Lobe_A.
DR   InterPro; IPR046770; DOCKER_Lobe_B.
DR   InterPro; IPR046773; DOCKER_Lobe_C.
DR   PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR   PANTHER; PTHR23317:SF26; ZIZIMIN, ISOFORM K; 1.
DR   Pfam; PF06920; DHR-2_Lobe_A; 1.
DR   Pfam; PF20422; DHR-2_Lobe_B; 1.
DR   Pfam; PF20421; DHR-2_Lobe_C; 1.
DR   Pfam; PF14429; DOCK-C2; 1.
DR   Pfam; PF11878; DOCK_C-D_N; 1.
DR   PROSITE; PS51650; C2_DOCK; 1.
DR   PROSITE; PS51651; DOCKER; 1.
PE   3: Inferred from homology;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274131}.
FT   DOMAIN          456..641
FT                   /note="C2 DOCK-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51650"
FT   DOMAIN          1317..1744
FT                   /note="DOCKER"
FT                   /evidence="ECO:0000259|PROSITE:PS51651"
SQ   SEQUENCE   1759 AA;  198879 MW;  B2C7C79427FDD722 CRC64;
     MAKNSIALTT VQFYARKPPI AQPLDYETFI TSKKADFDSD SQRELLLFPR DDISVSHEQG
     EPLWLLTQEA LKLYNSPTKC IEFNYAGFSG DYDSRTDADL NALSFESDLA LEEERAVFST
     SNVICEGYLF IVPESGLLDN FKSAKKRYCI FRKVDEGKVQ LELRKSPSIP PHNPPTPVKQ
     VYLTKTKKGK SVLEVVTLHH FLQISKLLSY TVVIGCSVCS YLPVVSTSFQ IEPFFVRLFL
     FDSRAGKRLS EEFRVSPKFG STALPDNESA AGSRNSLDED GLSVAQPHRE IYVVARVERV
     LSTDFSAEIY MKSNVDPKNV AKQIKSIQQA SSKLSKFRMP FAWAARPAFQ EMLGVAKLSE
     DISLYKWDGN KMSDSDLQKV LNDLANEKSG KLVPLPNGTM TLSVDISARV SEFPMRISPS
     FTPILPWNAA PDTLISPSFQ MQAFTDTVTE PYTALVNNLY VYPLLLKYDS QKIFNKARNI
     ACTVQFIASN ERGGNSVKAL YDRFAYPTPF VHRVRCTVQH HEQNPTFEEV SAIQGFQIKI
     RLPLTLDPSD HLLFTFTHIA ISSAMQKTNE IPAGYAWLPL VKNDRLVMEN DEQEVALPVA
     ADLPEGYITY QSLGLGKGHI GPDVRWVEGG KPLFRVRLRL ISSAFTTETK LQSFFQGCQK
     LQKIGLFANS QKVSITQAVN SDDLELEKCN RYVEIDRLVP FLPIVLGRLL SLLPSCATED
     MAITVLTLDF KSFKMVFSSE RVGDETTHSA ICKYQLLDRE LYKQESRHAG LTLWKTYYFL
     IASNDFIVTL ELLIGFKQKI LQVSRRERFP PEVFFRIRFF VEQMIPLIVL KHRDIPQETR
     VANTAIGYFF RVCFNDSYIF FCRCDFFIKL LKSLFSNFLQ HLREYKLDLL QILGGHEHWI
     PLALPLLCDS SGEIMKKDAI MADRNVSGKS LTQYAEEFTL TEGYCARHFL VGLLLQELQC
     SFREPRDYRR RTIMLVRNLL AKHSVDKRYL DSRAQVRIAT LYLPLLRLVL DYLGEMEVSL
     KTQDSSEQTV ASPAPVASSS AIPAIQSGSS FCSIDNYSES RDLLLCTMYI LHKVPQKVFE
     AVLKETETAG TGGMMDFIRL LELTLEFFKY RGLKFTLYRT SGRSESLPFS VLQESNLTQE
     IALRVLDIIQ ILAGGEDEDQ IFLKLLRLEV TLLGENWPDA VRLHTIASLA IFINMFRNRF
     FKTGPLEGLS VLVEALLLQL NSRLISIQCA AAALLHLVLR NGYEYQLQSG KIDSSQTSKQ
     VTSPAKGKRR LPKRESVLRT VECLGRPGSQ TGVALARYVY QKCFQIRVAD LHIQLADSYR
     GSSALRSAWF DTLAETHMRD RWFSEAAVCE CHVLAIIAKE LALSENVFSN ESETVEKAGF
     TMRNFTSKVE KTIQTLLLAE RYEAIGPICR LAIPLYEKLK DYRALVSMYV ELQQAYSLAD
     QVKITGKRHL GAYFRVFFYN ATLFGEEHKT EWIYREPGLT SLAEAYERMT NACQLALGHE
     KVQIVPEKEL DESKLDKGVA YVQMTHVEPA VGDCSDKTSF DAHTNLRRFI YECNDVDKTV
     PADAPTLARQ ALKKIYLTSK PLYPLSALAP FPNTCRRQRV VSREELFMNP LELAVDKLTF
     KADQIKKIIE QAAQCDGTKK SLLARLDVKG LQLLLQGAVQ PTVNVGPLAY AEAFTAPAQV
     ERYGQEGVKR LSDAFRKLMS VCADALQINE VAIGSDQAEY QQMLKNGFVA MMERLNSYFG
     DSVSFDFSNP NDSIGGLNA
//