ID A0A3P6SI79_LITSI Unreviewed; 948 AA.
AC A0A3P6SI79;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Cadherin domain-containing protein {ECO:0000259|PROSITE:PS50268};
GN ORFNames=NLS_LOCUS5 {ECO:0000313|EMBL:VDK67035.1};
OS Litomosoides sigmodontis (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Litomosoides.
OX NCBI_TaxID=42156 {ECO:0000313|EMBL:VDK67035.1, ECO:0000313|Proteomes:UP000277928};
RN [1] {ECO:0000313|EMBL:VDK67035.1, ECO:0000313|Proteomes:UP000277928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the calsyntenin family.
CC {ECO:0000256|ARBA:ARBA00035015}.
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DR EMBL; UYRX01000001; VDK67035.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3P6SI79; -.
DR STRING; 42156.A0A3P6SI79; -.
DR Proteomes; UP000277928; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0001540; F:amyloid-beta binding; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019894; F:kinesin binding; IEA:InterPro.
DR GO; GO:0042988; F:X11-like protein binding; IEA:InterPro.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 2.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 2.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR026914; Calsyntenin.
DR InterPro; IPR045588; CLSTN_C.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR PANTHER; PTHR14139; CALSYNTENIN; 1.
DR PANTHER; PTHR14139:SF2; CALSYNTENIN-1; 1.
DR Pfam; PF00028; Cadherin; 1.
DR Pfam; PF19699; CLSTN_C; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 2.
DR SUPFAM; SSF49313; Cadherin-like; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS00232; CADHERIN_1; 1.
DR PROSITE; PS50268; CADHERIN_2; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000277928};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..948
FT /note="Cadherin domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018007891"
FT TRANSMEM 821..847
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 73..149
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 150..257
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 854..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 888..933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 854..869
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 948 AA; 105687 MW; 62A68C09F18EED1A CRC64;
MPSKEFRLVI RPVVLQILVG AILTSATPSH RHRVPIIDLD GADELLGTIR EDRIVVNVNP
KLGIVHDTGP VCRYELTGDN LEDVPFTIDV HDEKEGSGVV RVKDGVHLDC TNSQSLVNVV
AVRCDDGARS ESARLRISVK DTNDHVPVFS HPWYTFNVYE GKIYNELARL QATDKDCGHP
YGQICRYQIT NALDGFPFAI DDQGVLRNIR PLNYTQAKSY ILTVVAHDCG MRQSKSTLVT
INVHEACVDG VHGIPERVTY TAGSGTMRIA PNAHVVTCAE AQSCTLESVK SILTLQTEHL
MSGCDRDDFV SEAVWNKCGM DGATVALLAA TDDSVTDKYV FDGKSTAVTV PQEKVGGVIP
LKFTLSFSMK HARGSKEEQA HKQTILCESD YTNMNRHHFA VYTRHCKLEM LMRRESNAEA
AFRAAEWRWS IPEVCDNRWH SYSILFESVA TVDLYIDGRK FIATKENPEI LDDWPLHHIK
DAKTRLVVGA CWHGRNRIMS QFFKGHLSSI YYLPHKLEQL HVLQCSHQCK EKLEFNAIDQ
LVPGENAIFT TDSSSLSLKA NTAEDLSLLL QRVTYANTKN LPTPGHRTFF VNTTVLCSDG
KTLILNPSKG SIVVQREAEP VISISGLSVV NSDQHLVKTG APMLPEIKIT VTQNVNGEEI
ERTSVSELDW CKVHLKPSRD MDLEYFSSPA SLIASLRIDF EHDKQGILLK GKEKVKGYRE
ILSKIHYFNT RADSYSRRIY TVQCAMSGGR ILSNEFLVTM NINTSLQSTE SPVTEILDDD
EMQVDPSFDR ISGNRLQNLL EMDLPPPRAL TSHHGYGVQG AIAGGAVAVV VVLCVGFLLV
MLVIGVVKMR DTPLPSRRRR NRRSTEGAME WDDSGMNITV NPLEEVDKSG VDFSDGESSD
GGESFHDEGL TEDEDAGHVL PHVDDERQNR SLEWDDTTLT NASRTYHV
//
