ID   A0A3P6SM79_LITSI        Unreviewed;       448 AA.
AC   A0A3P6SM79;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 12.
DE   RecName: Full=Saccharopine dehydrogenase NADP binding domain-containing protein {ECO:0000259|Pfam:PF03435};
GN   ORFNames=NLS_LOCUS1783 {ECO:0000313|EMBL:VDK72429.1};
OS   Litomosoides sigmodontis (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Litomosoides.
OX   NCBI_TaxID=42156 {ECO:0000313|EMBL:VDK72429.1, ECO:0000313|Proteomes:UP000277928};
RN   [1] {ECO:0000313|EMBL:VDK72429.1, ECO:0000313|Proteomes:UP000277928}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the saccharopine dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00038048}.
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DR   EMBL; UYRX01000069; VDK72429.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3P6SM79; -.
DR   STRING; 42156.A0A3P6SM79; -.
DR   Proteomes; UP000277928; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR005097; Sacchrp_dh_NADP.
DR   PANTHER; PTHR12286:SF5; SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE; 1.
DR   PANTHER; PTHR12286; UNCHARACTERIZED; 1.
DR   Pfam; PF03435; Sacchrp_dh_NADP; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000277928};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        15..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        284..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          15..148
FT                   /note="Saccharopine dehydrogenase NADP binding"
FT                   /evidence="ECO:0000259|Pfam:PF03435"
SQ   SEQUENCE   448 AA;  49807 MW;  9DB29C2A0EE15023 CRC64;
     MEQSSGALKM SRYDIVLYGA SGFTGAYVLK LLLEEQKQQS ISFAIAGRSE ARLRKLLNST
     GQDLGKDLRN ISIIIANSYD ESTLVAMAKQ AKVIINVVGP YRLYGEAVVK ASVENGASYV
     DISGEPAFLE SMQMKYNDIA QKNGLYVVGA CGWDSIPCDL GVNFLKEKFN GQLNHVETFV
     QLNTGPAGYS FNAGTYRTLV LGMANMMTDG LGKIRRTIMP ERLPKSSFRA PKRGTFWFNE
     KIDGWCLPFY GSDKSVVTRS QYFDYKFHNV LPVQVETFIR VKSFVWACLL SLWLVVFSAA
     AKVSFMKDFL LAYPGLCSFG MFKDSGPTAE QENQFPLILN LLLFLLKKIK QASFTYWFFG
     TGWTEKHSSL DEYKVKPNKQ MVARCVGPDA GYISTSACIL AAALSLLSDA DKLPQGGVYT
     SAAAFKDTGI YGRLERYGVR FEIVDEIN
//