ID A0A3P6T436_LITSI Unreviewed; 1185 AA.
AC A0A3P6T436;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN ORFNames=NLS_LOCUS3841 {ECO:0000313|EMBL:VDK77879.1};
OS Litomosoides sigmodontis (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Litomosoides.
OX NCBI_TaxID=42156 {ECO:0000313|EMBL:VDK77879.1, ECO:0000313|Proteomes:UP000277928};
RN [1] {ECO:0000313|EMBL:VDK77879.1, ECO:0000313|Proteomes:UP000277928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
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DR EMBL; UYRX01000223; VDK77879.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3P6T436; -.
DR STRING; 42156.A0A3P6T436; -.
DR Proteomes; UP000277928; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000277928}.
FT DOMAIN 1031..1047
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 52..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 832..859
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 53..102
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1185 AA; 134674 MW; BAEF98E57D45BF43 CRC64;
METISPSRGS KVQKKVNKEN DIQMEEDVTK SVLAKDFEGK IQILLNLFEA PHAKRPSNDE
FSSVKKSSTK RRRVVVSSES EDDDIEMVDI KKSKENMKQS PKHQSKSPKH GNIFSETSLA
DEPRSLKPIV SEMAISFINS FRATDQDSST AASRLHCSND KDVTDKNSSA GSFSTAMPDI
ESVRFPHLDF DFLQPDRIRD ADKRLRSHPD YCSRTLYVPE AFIKKQTPGH RQWWAAKSAY
FDTVLFFKVG KFYEMYHMDA VIGVENLNLN YMRGSFAHCG FPEVAYGRFA DQLVNRGYKV
ARVEQLETPT QLESRNKIEK ANDKVVKREV CNITTPGTRT YGVLDGNDEQ STVDMMDTTA
RYLYAIAERG TESVEYGFCF IDTTTGQFHI GSLSDGANRS DLRTLFSQYQ PAQILYERGR
VSASTMVVYN STVSAVPKEA LVPKKEFLTS ENTLKLLASD KYFGELYDEW PTVIRDAMDR
DSLALKCNPA YDACISALGA IIWYLERCFI DVDMLSMRRF ELYKSMNFTG PLLQDKDQLE
GDKQYWSGRR LILDSLALKH LNIIPPIGSI RKFSPYDPVT AKYTLYNVIN KCVTPAGKRL
LRQWVCAPVC DREVLCSRQD AIEWLSEAKL KVFINKAMER LRKVPDLERL VQKIHTLGLK
YRAEQHPDSR AQMFETIRYN KRKIRDLVRA LEGFECIHDV RLEFMENFSE SRETMYVACP
SLLERCFGDR FPDISSDLEH FKSAFNRDKA QEEGIIVPEK GVIKDYDDAI SYTKECIREL
DLYLNVIRKQ LHCSNINFFG SGRSRYQLEI PETVAMNLGH EFELKSSRKG YKRMVTDELV
KLVKNLDEAE NQLDVLQRDI MRRVFSDFGD RSAKWIAVIE RMATFDVLLS LTRYGQECGL
NVCRPQFVYD SEQPVLKIKS GYHPSLAAIA ASGNSFTYIP NSVSLGGNDS STILLTGPNM
GGKSTLMRQV GVLVVLAQIG SFVPADEMEL SPVDRIFTRM GAGDRITAGQ STFYVEVYET
NLILRNATRH SLIIMDELGR GTSTYDGTAI AYGVLLDIAT RLNCRTFFST HYHSLCKAVE
NLSNIKTAHM ACVVENEDAE DPTMENVTFL YTLTNGVCPK SYGFFAAKIS GLRKEVIRAA
FAASRHLHEG KTRKERMEKL RRLALSEECS TAQLREVINS MLISS
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