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Database: UniProt
Entry: A0A3P6T7F8_LITSI
LinkDB: A0A3P6T7F8_LITSI
Original site: A0A3P6T7F8_LITSI 
ID   A0A3P6T7F8_LITSI        Unreviewed;       425 AA.
AC   A0A3P6T7F8;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   03-MAY-2023, entry version 15.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:VDK79219.1};
GN   ORFNames=NLS_LOCUS4417 {ECO:0000313|EMBL:VDK79219.1};
OS   Litomosoides sigmodontis (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Litomosoides.
OX   NCBI_TaxID=42156 {ECO:0000313|EMBL:VDK79219.1, ECO:0000313|Proteomes:UP000277928};
RN   [1] {ECO:0000313|EMBL:VDK79219.1, ECO:0000313|Proteomes:UP000277928}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UYRX01000282; VDK79219.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3P6T7F8; -.
DR   STRING; 42156.A0A3P6T7F8; -.
DR   Proteomes; UP000277928; Unassembled WGS sequence.
DR   GO; GO:0047710; F:bis(5'-adenosyl)-triphosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   CDD; cd01275; FHIT; 1.
DR   CDD; cd07572; nit; 1.
DR   Gene3D; 3.60.110.10; Carbon-nitrogen hydrolase; 1.
DR   Gene3D; 3.30.428.10; HIT-like; 1.
DR   InterPro; IPR003010; C-N_Hydrolase.
DR   InterPro; IPR036526; C-N_Hydrolase_sf.
DR   InterPro; IPR039383; FHIT.
DR   InterPro; IPR019808; Histidine_triad_CS.
DR   InterPro; IPR011146; HIT-like.
DR   InterPro; IPR036265; HIT-like_sf.
DR   InterPro; IPR045254; Nit1/2_C-N_Hydrolase.
DR   PANTHER; PTHR23088:SF27; DEAMINATED GLUTATHIONE AMIDASE; 1.
DR   PANTHER; PTHR23088; NITRILASE-RELATED; 1.
DR   Pfam; PF00795; CN_hydrolase; 1.
DR   Pfam; PF01230; HIT; 1.
DR   SUPFAM; SSF56317; Carbon-nitrogen hydrolase; 1.
DR   SUPFAM; SSF54197; HIT-like; 1.
DR   PROSITE; PS50263; CN_HYDROLASE; 1.
DR   PROSITE; PS00892; HIT_1; 1.
DR   PROSITE; PS51084; HIT_2; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000277928}.
FT   DOMAIN          6..255
FT                   /note="CN hydrolase"
FT                   /evidence="ECO:0000259|PROSITE:PS50263"
FT   DOMAIN          290..397
FT                   /note="HIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51084"
FT   MOTIF           382..386
FT                   /note="Histidine triad motif"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00464"
FT   ACT_SITE        384
FT                   /note="Tele-AMP-histidine intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR639383-1"
FT   BINDING         315
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
FT   BINDING         371
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
FT   BINDING         377..380
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
FT   BINDING         386
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
FT   SITE            403
FT                   /note="Important for induction of apoptosis"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR639383-3"
SQ   SEQUENCE   425 AA;  48215 MW;  9F581ED7191430E6 CRC64;
     MNEVRSLIAV CQLTSTNDLE ANFKVAERMM KHAKERNAKM VFFPECFDYV GENRHESATL
     ALTEDGDYIG RYRNCAREYG LWLSLGGFHQ KDPAGLQKPF NTHLIIDDGG KTRGMYRKLH
     LFDIDIPGKV RLIESEFSSR GDEILKPVCT PVGNVAMSIC YDLRFAELAL WYRMNGAHIL
     TYPAAFTVNT GLAHWETLLR ARAVETQCYV IAAAQTGKHN DKRSSYGHSM VVDPWGTVVA
     QCSETIDMCF AEIGLNYLDE IRKLQPVFDH RRSDLYSLIA VQKNEIGNKA YTFGNQSIPP
     EHVFYRSTYT FCFVNRNPVL PGHVLLCPIR NVKRLAKLSH AETSDLFITA KRVQAMLEDY
     HKVASSTVCV QDGPEAGQTV SHVHVHILPR KKDDFGGDAN NIYRELAEDD KITKRKFRKK
     PSDNV
//
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