ID A0A3P6TPB2_LITSI Unreviewed; 630 AA.
AC A0A3P6TPB2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 13-SEP-2023, entry version 12.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=NLS_LOCUS5121 {ECO:0000313|EMBL:VDK80980.1};
OS Litomosoides sigmodontis (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Litomosoides.
OX NCBI_TaxID=42156 {ECO:0000313|EMBL:VDK80980.1, ECO:0000313|Proteomes:UP000277928};
RN [1] {ECO:0000313|EMBL:VDK80980.1, ECO:0000313|Proteomes:UP000277928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UYRX01000365; VDK80980.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3P6TPB2; -.
DR STRING; 42156.A0A3P6TPB2; -.
DR Proteomes; UP000277928; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113:SF327; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP, ISOFORM E; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000277928}.
FT DOMAIN 1..48
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 109..248
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 392..625
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:VDK80980.1"
SQ SEQUENCE 630 AA; 71712 MW; A15564DBBC961699 CRC64;
GVICTLREGD DFGKLALVND GPRAATVVLR NDKSQFLRVD KHDFHRILRD VEANTVRVKE
DGEDVLVLEK MNSIYQAFDD TYSLSQAPEI NTSGTNSAGD LVMHLRPKCC YSVMAGMPEK
ILEYLLETRI DAQTDDGLMD TFLEDFILTH ITYLPVNILC SYLKNYYMRG STARMDGAQS
VNNYGHKIVV KRRVITFLNL WVQILGLRFF LDPASNSFIE ELYCYVLEDS QQIPEMLAIL
PSMCAVRQLR ESAMQTINRH SSVVLDCGAY GAQAPAPNPI LPFDTCNQVI YLSDARSFVM
SIRFDKTAAD ICEMAKAKVC YSGTSEQLKL VEVKSSGEKI VFAPTDISIP TMISLNGRLF
IVCSDEIETL KPTMQQNGSF GSIHSSLLDY LSSVDIAQQL LIFHTQLLEA TDDIELIIQV
FGREQFPSRI TSNLDLLMRR FNEVQFWTTT EVLLAGDSTK RLAILKKFIK IAAYAKENRD
LLSLFAIILG LSNVAVSRIT HLWDKLPNKM KQQYTEFEEL LDPCRNHRAY RMLTANMTAP
TVPFIPLLLK DLTFTHEGNK TYFAGLINFE KMHMIANVLR SFRQCKYPAV AFERKVFKSK
SLVKNLKVID NQRRLMELSY QIEPMKKKRL
//
