ID   A0A3P6U1C3_LITSI        Unreviewed;       575 AA.
AC   A0A3P6U1C3;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:VDK89549.1};
DE   Flags: Fragment;
GN   ORFNames=NLS_LOCUS9180 {ECO:0000313|EMBL:VDK89549.1};
OS   Litomosoides sigmodontis (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Litomosoides.
OX   NCBI_TaxID=42156 {ECO:0000313|EMBL:VDK89549.1, ECO:0000313|Proteomes:UP000277928};
RN   [1] {ECO:0000313|EMBL:VDK89549.1, ECO:0000313|Proteomes:UP000277928}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UYRX01001412; VDK89549.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3P6U1C3; -.
DR   STRING; 42156.A0A3P6U1C3; -.
DR   Proteomes; UP000277928; Unassembled WGS sequence.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 3.30.60.20; -; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   InterPro; IPR046349; C1-like_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000277928};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          173..208
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          241..270
FT                   /note="Phorbol-ester/DAG-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50081"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:VDK89549.1"
SQ   SEQUENCE   575 AA;  64872 MW;  ADAD5D5D6AB90405 CRC64;
     SLSNWVQCMI LSKGTPVERA GMITKFIHVA KCAKLEIIPG AESIYTTSFF NIELCLLSQS
     IAQECGFLLH SNHLVIANGL SYRGVHLKDL ISLLIKSEES SEHCCLVSCR QIPYLAIHLS
     YFVNFNRTPH NFPDANIDLI DTLKFPSTTK SVLFADWASG VSSALDAEIV NKHINAMVEA
     VFKNYDHNKD GSISQSEFQQ ISTNFPFIAS FGTIDTDNPV NMRSDEIRIE NFIKLALKVH
     LWGILRQGFK CHDCGLTVHR TCRDNVVVEC RRTSNWKTTV TESAKITRKF LPSIGSLPRL
     RTTSTTLEHD EEDDIARASA TCKIFSHLQP HLKMDCTRSD TGCYYQVTSS PESSHAEVVP
     SLACEEVFED EFSCISISGM DRCKGKKLIS YDLCLLISRC IIWADFVMLN DLNWGHFLPI
     QADDELVADR VCVKIDERLE EVRCVGPCLA LNVTVSEDGN TRTIGSSGML RDCQKKYYSR
     DSYNDEGNRR CRNRTVKIRQ RVLHAEYCFC LGSYCNGDDD MLARSVSEFR KLSKYTKSGS
     SERSGSTTTK WSLYNDAKYL LAVCVVCWKL HSIIL
//