ID A0A3P6U316_LITSI Unreviewed; 817 AA.
AC A0A3P6U316;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 13-SEP-2023, entry version 12.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=NLS_LOCUS1283 {ECO:0000313|EMBL:VDK70981.1};
OS Litomosoides sigmodontis (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Litomosoides.
OX NCBI_TaxID=42156 {ECO:0000313|EMBL:VDK70981.1, ECO:0000313|Proteomes:UP000277928};
RN [1] {ECO:0000313|EMBL:VDK70981.1, ECO:0000313|Proteomes:UP000277928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UYRX01000043; VDK70981.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3P6U316; -.
DR STRING; 42156.A0A3P6U316; -.
DR Proteomes; UP000277928; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF312; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE, ISOFORM E; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000277928}.
FT DOMAIN 62..188
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 233..499
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 657..752
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
SQ SEQUENCE 817 AA; 92900 MW; E3C56D4997F62ACC CRC64;
MTAAKYFGEE KLEDAIYEIY LRKVRYVSPI NVESSDDRAT DIKRYGCSVD NTSDHLHWET
IRERIIRAGT LEKLVECLIS DDMLMDSRHF NVFFATYRSF ATCSNVLELL LQRYVSLDMN
SLVIGKAKAV TLQCSLRSVI MCWLEMYPED FNEPSDDFAT LMRLIEFGRI HKIADLRTKA
RQLRETYKRQ VMDGRYLAQI PSMEQYVFST GYDTPDFDAC VQRANMFDIG RENCVQIAEQ
LTFWDSELFK ELLPQQCQGC VWNKRNKRGR ETVYTVRATI DQFNAVVQKV MTSVVLPNCS
PDFRAKIIAK WIDVARELRA LKNFSSLKAI ISTLQSEPVH RLKSTWAQVP SASLAEFREL
ASIFDTDDDG DERRARQILE EEGTAKKSPL RRPQLIQNCR RTKSDVNLAE SQGTVPYLGT
FLTDLSMIDQ ANPDFTEEGL INFEKRRKEF EIIAKIRLFQ SACRAYKIPM DMAFCSWFCF
LPALDENQCF IRSLEVEIPT NQADSSKLFR SQVPKVNTLS RLISGMTIDE TPNDSGQISN
DSGIVTEDLW YDGVTKPFAE KALITACSPF GIASSRSFTA HSMPSNTVLW KDSQFNPNAA
FSHRRSTSGC WDKKNHSNDV SVGSLLNAHD NMFSSLRTPE TSSGSCVSAN SLQQTASFHL
ARVALDDSMK DDDTGTANYK CIKIINGDKM AELIERTLEK HLISGDHSEY CLVQLLPDGC
EFCLPEKCNP YYAVAPDPTS TMLNFVLRRK SDVERSGGVA SSAKKLNKMK RCNLLRWSSA
IISRTSDYEA KWKVFLWSPA KIILSMGTLV AKLLLLW
//
