ID A0A3P6UFV7_ONCOC Unreviewed; 1450 AA.
AC A0A3P6UFV7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:VDK77104.1};
DE Flags: Fragment;
GN ORFNames=NOO_LOCUS5354 {ECO:0000313|EMBL:VDK77104.1};
OS Onchocerca ochengi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=42157 {ECO:0000313|EMBL:VDK77104.1, ECO:0000313|Proteomes:UP000271087};
RN [1] {ECO:0000313|EMBL:VDK77104.1, ECO:0000313|Proteomes:UP000271087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; UYRW01001402; VDK77104.1; -; Genomic_DNA.
DR Proteomes; UP000271087; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 8.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 13.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 4.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR003410; HYR_dom.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR12916; CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2; 1.
DR PANTHER; PTHR12916:SF4; NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1-RELATED; 1.
DR Pfam; PF00008; EGF; 7.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07699; Ephrin_rec_like; 4.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF02494; HYR; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR SMART; SM00181; EGF; 15.
DR SMART; SM00179; EGF_CA; 12.
DR SMART; SM01411; Ephrin_rec_like; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 6.
DR PROSITE; PS00022; EGF_1; 12.
DR PROSITE; PS01186; EGF_2; 8.
DR PROSITE; PS50026; EGF_3; 14.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50825; HYR; 1.
DR PROSITE; PS50923; SUSHI; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000271087};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1343..1367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..45
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 47..85
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 87..125
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 127..163
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 165..200
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 202..238
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 240..276
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 278..317
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 319..355
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 357..393
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 395..431
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 433..470
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 724..803
FT /note="HYR"
FT /evidence="ECO:0000259|PROSITE:PS50825"
FT DOMAIN 804..874
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1253..1296
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1298..1333
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 35..44
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 56..73
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 75..84
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 115..124
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 153..162
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 169..179
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 190..199
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 228..237
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 266..275
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 288..305
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 307..316
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 345..354
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 383..392
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 421..430
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1301..1311
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1323..1332
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:VDK77104.1"
SQ SEQUENCE 1450 AA; 161155 MW; 322A0C112CD7C797 CRC64;
YTGKYCEEQM PLCDTQPCFN EGICEAAAGT FRCICAQNYT GSRCQFGPDE CIGMSCPNGG
VCHDSPGLGT TKCICRSGFT GPDCSQIVDP CFMENPCKHG ADCIPLQLGR FKCKCLPGWT
GPTCSINIDD CADNPCAMNA TCTDLVNDFR CECPPGFTGK RCHEKTNLCA QNPCINGLCV
DMLHTQRCIC EPGWTGEICD VKIDQCASHP CLNGATCKDQ IDGFSCQCAP GFHGFLCQHM
TDHCATSPCR NDATCVNQGV QYMCECSLGF EGAHCEHNRN ECDLLHKCSQ EGTELCEDLI
NGYKCNCRHG YTGELCEIHI DQCASEPCLN NGTCIDTGSQ FRCDCPRGWK GNRCEEEDGL
CALNPCHNNA HCVNLVGDYF CVCPEGVSGK DCEIAPNRCL GEPCHNGGVC GDFGSHLECT
CPKDFIGTGC QYELDACQEG VCQNDAVCEL LEGGNYRCIC EPGEIFDYSF DKYTFRTDKQ
VDGFFCQCPF NMTGLNCDKI IDEDYDFHFY DPILPAAAAL SVPFKFTSSA FTISLWVKFD
VPLTRGTVLT LYNSRESNYP SKISELLRIS ADNIHLNLLH DETPLNLHFP STQRLNDGNW
NNLVITWQST DGSYSLIWNA VRIYADIGYG TGKILDINAW ISLGEPINEF SNEPKFVGSI
TRVNIWKRVI DFEVEIPSIV HRCQQQQVIY NDLVLRFAGY TRLSGKVEKV VRSSCGRDRD
NIRQHSKKIE VLGCPSDIFV TAQQKEVNIT WQEPIFTSVK GNVEVKRNLK PGQVFTWGEY
LVVYLANDNH SMAECIFKIH VSREFCPTLQ DPLHGVQACE SWGPQLRYKA CSIECENGYE
FSIEPPVFYT CSSDGQWRPR PANAYTFRYP QCTKAHPAIR VAEISINYPT VSICNLAGRN
TLAEKLAQRI ELLNSKWNFY STSNVSDHST FNISVQCFAG NEETTVTPTD TTVRLRRETQ
NFFNVKVSIP ITNDILENRK TGQRAKVSDV LQNEILLEDI FSLEQVIPNG RPDLNSFELK
EQHICEMGTV NVRNLCVPCA PGSFYDSTTR TCKLCMIDEY QPRAAQSSCL PCPRGYITTA
PGSALLTDCK NVCEAGSMFN ISSGSCEPCG FGFYQSVSGA FNCIPCGVGK TTLKETSTAE
DECRDECPDG EHLTQAGVCL PCPQGTYRTR GVHKSCVDCP PGTTTEGTAS VRRMQCNTPK
CSAGQFLVTT TKQCQFCPRG TFQNEEIQTV CKLCPSDHTT AAQGATQASQ CYSTNQCATG
EDNCSWHAVC IDLPDDNDIP SYQCKCKPGY KGNGTHCQDA CNNFCLNDGT CKKNPIGYVE
CICKENFSGD RCEVRFQART QKVALITAGI GGVVTILVII VVIIWMISYR FNRVEDSSEP
EKCPVEENTH TNFLYGRVPS EQPRPIGYYY EDDDEYDMKT MFVGEEEKEM AERIRHAQAH
MYTPSNNRLD
//
