ID A0A3P6ULA5_LITSI Unreviewed; 1005 AA.
AC A0A3P6ULA5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 08-NOV-2023, entry version 21.
DE RecName: Full=Serine/threonine-protein phosphatase {ECO:0000256|RuleBase:RU004273};
DE EC=3.1.3.16 {ECO:0000256|RuleBase:RU004273};
GN ORFNames=NLS_LOCUS3912 {ECO:0000313|EMBL:VDK78021.1};
OS Litomosoides sigmodontis (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Litomosoides.
OX NCBI_TaxID=42156 {ECO:0000313|EMBL:VDK78021.1, ECO:0000313|Proteomes:UP000277928};
RN [1] {ECO:0000313|EMBL:VDK78021.1, ECO:0000313|Proteomes:UP000277928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] +
CC phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:83421; EC=3.1.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001512};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:61977; EC=3.1.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001482,
CC ECO:0000256|RuleBase:RU004273};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the PPP phosphatase family.
CC {ECO:0000256|RuleBase:RU004273}.
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DR EMBL; UYRX01000229; VDK78021.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3P6ULA5; -.
DR STRING; 42156.A0A3P6ULA5; -.
DR Proteomes; UP000277928; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR InterPro; IPR031675; STPPase_N.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF252; ANION TRANSPORTER SULP-8A; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF16891; STPPase_N; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR PRINTS; PR00114; STPHPHTASE.
DR SMART; SM00156; PP2Ac; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS00125; SER_THR_PHOSPHATASE; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU004273};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000277928};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 404..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 458..490
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 527..677
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
SQ SEQUENCE 1005 AA; 113075 MW; 5D74D68475CC38DE CRC64;
MDQETFELRY SRSQPQAKKL WSIEKLKLKL LPRNILKSVL SFFPILYWLP KYDWKRDLSG
DIIGGLTVGV MQVPQGMAYA NLASLPPVYG MYTSFFTSTF YAFFGTSRHI SIGVFAVASL
MVGTVRLRFI PDPDVIFEVV NGTGTEIVKS VAGPVDFSND VSPIMLTSTL AMTVGLFQLV
MAMMGLAFIT NYMSDALISG FTTGSAFHVF IAQLNKIIGV KLSRYSGFGM LFFMMRDLIL
AVPHTNCWTL GISLASILFL SIGRDYINPW FKKRSPVPLP VELILIILVT IFSVFMDLKN
SYEVKIVDYV PQGFPTPSLP NFDLIPYLLN DAFAIAIISY MFVISMAKLL AKKRRYKIDP
TQDLYAVGLM HTLASFFPIF PAGGSLSRSA VCEQAGANTQ LNILFSNALL LIVIAFTGPL
LEPLPMCVLA CIVIVSLRSL FMQFGDLSRL WRISKFDFAV WLVSCIATVS FDVMTGLTIS
VLFTLISVVL REQRPNIYLM GRTAHREIYK PLIYYRSLKL INENTGILRF EASLTFVNVA
TFCDKVNDIL LGDASEDCKL RNVKNDEVVL SKTERERNCE ELLQKEVVVA TNSKQQSSYE
IAPPSTLIID CGAISNIDTM GVEAIKEVYL QGKEMNKTIL FANMSETILD TLDRIDFYCL
VPKTSFYPSV EEAARSASSD PLISKSKENY LLSKMAAFDV DNMISRLLNV GMAGGRLTTQ
VAEEELHRVC QKAKEVFISQ SSLIEVDPPL VVCGDIHGQY SDLLRIYDRH GFPPEANYLF
LGDFVDRGKQ NIETICLQFC YKIKYPENFF MLRGNHETPA INRVYGFFEE CNRRYHSTRL
WNAFQDTFNW MPLCGYIGGR ILCMHGGLSP HLNNLDQLRN LPRPIDPPNP SMEIDLLWSD
PDQWVKGWQA NTRGASYTFG QDVVVDMCQK LDLDLIARAH QVVQDGYEFF ANRRLVTIFS
APHYCGQFDN AGGTMSISED MNCSFQIFRP ASKAVRMAMK AAGTL
//