ID A0A3P6USA6_LITSI Unreviewed; 278 AA.
AC A0A3P6USA6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=Thyroglobulin type-1 domain-containing protein {ECO:0000259|PROSITE:PS51162};
DE Flags: Fragment;
GN ORFNames=NLS_LOCUS5661 {ECO:0000313|EMBL:VDK82248.1};
OS Litomosoides sigmodontis (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Litomosoides.
OX NCBI_TaxID=42156 {ECO:0000313|EMBL:VDK82248.1, ECO:0000313|Proteomes:UP000277928};
RN [1] {ECO:0000313|EMBL:VDK82248.1, ECO:0000313|Proteomes:UP000277928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR EMBL; UYRX01000439; VDK82248.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3P6USA6; -.
DR Proteomes; UP000277928; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd16234; EFh_SPARC_SMOC; 1.
DR CDD; cd00191; TY; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR019577; SPARC/Testican_Ca-bd-dom.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR12352; SECRETED MODULAR CALCIUM-BINDING PROTEIN; 1.
DR PANTHER; PTHR12352:SF30; THYROGLOBULIN TYPE1 REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF10591; SPARC_Ca_bdg; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00500}; Reference proteome {ECO:0000313|Proteomes:UP000277928};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 42..112
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..59
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 82..89
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:VDK82248.1"
SQ SEQUENCE 278 AA; 32131 MW; 346A55F8B2C57877 CRC64;
IVHAGSIVGM PIVDSKRKNE TELKREKDEE ERNDAKDDTF GKTDCRTQRE RAMKKSENNP
EHRNYIPTCA GDSDILFDRI QCHRLSHICW CVNPDTGIPQ SGTSKYNAKP NCDGRLQRDD
ATRRQIKGGI NFAEIEIVAN GVGCLGRKKA KFYQRLFSSL ISEWILAVGD EANDDAITSK
DKAVRWKFEQ LDVNNNSRLE RKEWKSYRNE LRLFNKVRKC GRNFLRFCDR DGNKQIRLDE
WLNCTIYVDM TVSSMPAAKT KVILPRKNPF LDILQPDD
//
