ID A0A3P6UYM3_LITSI Unreviewed; 714 AA.
AC A0A3P6UYM3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:VDK83304.1};
GN ORFNames=NLS_LOCUS6140 {ECO:0000313|EMBL:VDK83304.1};
OS Litomosoides sigmodontis (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Litomosoides.
OX NCBI_TaxID=42156 {ECO:0000313|EMBL:VDK83304.1, ECO:0000313|Proteomes:UP000277928};
RN [1] {ECO:0000313|EMBL:VDK83304.1, ECO:0000313|Proteomes:UP000277928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UYRX01000520; VDK83304.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3P6UYM3; -.
DR STRING; 42156.A0A3P6UYM3; -.
DR Proteomes; UP000277928; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:InterPro.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR CDD; cd10422; RNase_Ire1; 1.
DR Gene3D; 1.20.1440.180; KEN domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR045133; IRE1/2-like.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR038357; KEN_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR13954; IRE1-RELATED; 1.
DR PANTHER; PTHR13954:SF6; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR SMART; SM00580; PUG; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51392; KEN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000277928};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 239..496
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 505..633
FT /note="KEN"
FT /evidence="ECO:0000259|PROSITE:PS51392"
FT REGION 659..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 714 AA; 81968 MW; B1B8D9C11DA02E37 CRC64;
MQHFYLHSSQ NGVQAWIDDV YQARPVEATS PNLFQTLYVG ESIHGLFALP AFVDSHTITM
VPKYLGPPLL EGPTPIAAEK DVQSSLFTRP AALINLDAAK ITHKTVDGEF LVLGYHELPQ
LTQSQLISQR ITRQQRYRSL PFVAKEAQSD EVSVQTAKID ERASWRRNHL VIIIVISFTA
LFASTCWFFR EKLRNQKQEN SPERRTIYAQ TSKIFRNFWC ARQLELLPHG WLQAGNIMYN
PEDRLGHGCE GTVVFRGKFD GREVAVKRVI ADIRLADREV DLLRESDTHR NVIRYFCMES
DSNFRYIALE LCDYSLFDYV ERQEIREKCP LVPLEILHQA TEGLAYLHSI NIVHRDMKPQ
NVLLSRGGKQ GTVRALISDF GLCKRLQAGR NSLSRRSGLV GTDGWVAPEA LMPDASITCA
VDVFSLGCVY YYVLTTGGHP FGDALKRQAN IMQGEYSLKF LSTSGNLMAV TLIETMLRRD
PFLRPISATL AVHPFFWNKE HQLSECMKFA LFKDVSDRIE KLNEHTFLLR RIEENARYAI
GFNWHLSICP VLAADLRKFR TYKGTKVRDL LRAMRNKKHH YQELPKEVQQ TLGQIPDQFV
TYFTDRFPQL LQHTYDAMSC CANEHAFTKY YSEEARRKAD QFAVEMAESV IKELEIENKE
KEIVDGPDED NQDGGMTVDE PFVQEGGTVT VDDPTIEADN SRRSRKRKKR PKQH
//
