ID A0A3P6V5Q2_LITSI Unreviewed; 561 AA.
AC A0A3P6V5Q2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 22-FEB-2023, entry version 12.
DE RecName: Full=heparosan-N-sulfate-glucuronate 5-epimerase {ECO:0000256|ARBA:ARBA00012087};
DE EC=5.1.3.17 {ECO:0000256|ARBA:ARBA00012087};
GN ORFNames=NLS_LOCUS7158 {ECO:0000313|EMBL:VDK85514.1};
OS Litomosoides sigmodontis (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Litomosoides.
OX NCBI_TaxID=42156 {ECO:0000313|EMBL:VDK85514.1, ECO:0000313|Proteomes:UP000277928};
RN [1] {ECO:0000313|EMBL:VDK85514.1, ECO:0000313|Proteomes:UP000277928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[heparosan-N-sulfate](n) = [heparan-N-sulfate](n);
CC Xref=Rhea:RHEA:20197, Rhea:RHEA-COMP:9556, Rhea:RHEA-COMP:9557,
CC ChEBI:CHEBI:58041, ChEBI:CHEBI:58287; EC=5.1.3.17;
CC Evidence={ECO:0000256|ARBA:ARBA00000434};
CC -!- PATHWAY: Glycan metabolism; heparin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004841}.
CC -!- SIMILARITY: Belongs to the D-glucuronyl C5-epimerase family.
CC {ECO:0000256|ARBA:ARBA00005584}.
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DR EMBL; UYRX01000700; VDK85514.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3P6V5Q2; -.
DR STRING; 42156.A0A3P6V5Q2; -.
DR UniPathway; UPA00862; -.
DR Proteomes; UP000277928; Unassembled WGS sequence.
DR GO; GO:0047464; F:heparosan-N-sulfate-glucuronate 5-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:InterPro.
DR GO; GO:0030210; P:heparin biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR010598; C5-epim_C.
DR InterPro; IPR039721; C5-epimerase.
DR PANTHER; PTHR13174; D-GLUCURONYL C5-EPIMERASE; 1.
DR PANTHER; PTHR13174:SF3; D-GLUCURONYL C5-EPIMERASE; 1.
DR Pfam; PF06662; C5-epim_C; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000277928}.
FT DOMAIN 360..551
FT /note="D-glucuronyl C5-epimerase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06662"
SQ SEQUENCE 561 AA; 64406 MW; 457AD9F3B75489DA CRC64;
MHEVDEVESK SSGLKEISCV VDNEKTYKCY EEEITNEVYF PFNAFLRKRF DVSGKIFRES
NSVAKHFEWS TSRARVRFPD FVSYDHRGAF GHFASYSVET RDRVRCISAQ YGVPLSTQWS
TVPYFYPIQI AQYALQHYSR FKTGEYFEIF EANVFVKCPS SIAFVKGGRT EEWNDNTHGG
DSFKLSFDEK ANCTRVEINS DDHGVLLQLD GNPAFSVLSF FWLADVDASF TIILKLVYFG
LFYHPFLQNQ KIIRLHYVHN DDEQCVSHDK KTTKNDYNYS LGANPNPNEW RWICRDLLVD
AGRALVSTSN KKEITLLHPG DIVLDSITFR GRSVIRDFKQ RSSAHLEHFL IAADWLASNQ
DELGGWSVPV ERSMADKRLI LPAGWHSAMA QGHALSVLTR AYIVTNDEKY LQVAKRALYL
FKAEAAKGGV LNELFGHPWF EEYPTTPGTF VLNGFLYSLI GLYDFSQVSN SQNAENDSTT
LFSVGLESLR IFLPLFDSGS GTFYDLRHLG VKMAPNLARW DYHSVHIYLL KWLYIITKDE
FLNETANRWA SYATGHRAKH N
//
