ID A0A3P7D7X8_NIPBR Unreviewed; 651 AA.
AC A0A3P7D7X8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Ion transport domain-containing protein {ECO:0000259|Pfam:PF00520};
GN ORFNames=NBR_LOCUS19222 {ECO:0000313|EMBL:VDL82951.1};
OS Nippostrongylus brasiliensis (Rat hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX NCBI_TaxID=27835 {ECO:0000313|EMBL:VDL82951.1, ECO:0000313|Proteomes:UP000271162};
RN [1] {ECO:0000313|EMBL:VDL82951.1, ECO:0000313|Proteomes:UP000271162}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; UYSL01023990; VDL82951.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3P7D7X8; -.
DR STRING; 27835.A0A3P7D7X8; -.
DR Proteomes; UP000271162; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR024862; TRPV.
DR PANTHER; PTHR10582:SF19; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10582; TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000271162};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 342..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 415..436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 456..477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 483..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 511..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 588..610
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 175..207
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 423..622
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
SQ SEQUENCE 651 AA; 74196 MW; 47E29A47B559B814 CRC64;
MFFCCFSSID KGSSSRFSGQ RTRGLNHDEI RACCGGRRRP GGRPPPGRYE AVSNVSEFLL
NNEKGKLFAI TELVTLRNKE RNAKLGAFLR KKGKGKAAVN VLEGFDQADA KTGDLKKALK
LLDGGGKGGK SESKYRELNW KLEERGTTMH NLLALRILDF YPKLLNDICT SEDYYGLSPL
HQAIINHDVQ MVGKLLRRGA DVNQRTMYFG EYPLSFAVCM NQPDLFRLLE MMTLALEAGA
RLNIPNKQNL TPLTLAAKLA KKKIFNIILE LEGQSVWVYG SASCFSYPLT KIDTINEVTG
EMNEQSALSL VVYGKTSAHL ELLDGILEKI LDEKWKAFGK RYWFRSLISF TVYYVIFTAA
YMLRPFSATT EQITGGAITA NGTISPSGFA WSRQDQENAN CHLLQYWRWN WDEGWVRLGC
EVVVVILVIV QIFLDVRDIR RIGRAKWFTV MVPVRFSCNL HSAFLIADNV IAAIAVLFTS
IHYLYYCRAI PFIGPFVLMV YTIIATDLTR FIVIYSIFLV GFSQAFYIIF TACERASKEI
EKNGGKSEFE NVIDNPLEAL LRTFIMTIGE FMTLYKEMAS CEAKLMNFIG KIIFLVFEIF
VSILQFNLLI AMMTRTYETI FETKREWNRQ VNTNYRKCFH SDLLGTERLR L
//
