ID   A0A3P7IB59_ANGCS        Unreviewed;      1081 AA.
AC   A0A3P7IB59;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE            EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
GN   ORFNames=ACOC_LOCUS12384 {ECO:0000313|EMBL:VDM63969.1};
OS   Angiostrongylus costaricensis (Nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Metastrongylidae;
OC   Angiostrongylus.
OX   NCBI_TaxID=334426 {ECO:0000313|EMBL:VDM63969.1, ECO:0000313|Proteomes:UP000267027};
RN   [1] {ECO:0000313|EMBL:VDM63969.1, ECO:0000313|Proteomes:UP000267027}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Costa Rica {ECO:0000313|EMBL:VDM63969.1,
RC   ECO:0000313|Proteomes:UP000267027};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00001436,
CC         ECO:0000256|RuleBase:RU003431};
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000256|RuleBase:RU000405}.
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DR   EMBL; UYYA01005014; VDM63969.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3P7IB59; -.
DR   STRING; 334426.A0A3P7IB59; -.
DR   Proteomes; UP000267027; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR018297; A/G_cyclase_CS.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   PANTHER; PTHR11920:SF335; GUANYLATE CYCLASE 32E; 1.
DR   PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF00211; Guanylate_cyc; 2.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
KW   cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW   ECO:0000256|RuleBase:RU003431}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000267027};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        494..521
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          506..805
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          874..980
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   COILED          814..845
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1081 AA;  124684 MW;  037D0F3F096F2521 CRC64;
     MIDYCYYCLQ ILFIFLFIFR VNVTFFCVIR TQYAPRVSST LVINSVGVSI ATMPNLEFAR
     DEINANPDLL PDHRLSYIFD NTCGKERQST QYFMEHWKMG ARVFIGPEMN CRTEATMAAA
     QNLPIISYKC KDQTVSDKKK YNTFARTVPA ETDIVKAFIA LCREYKWKKF TVIYEEHPAH
     EELYQALQNV SKVVRFSEVQ SEKLIDSVIE QTKDITRCEC LAKSVIALYV TFGNVRLFRK
     ILMSMGKLGL TDSQQYLLIY LDADYNWLNV YHAMNNHFFR NTMIDLQSSW DVSNSSDHRI
     IGYSRAALAI IPTPVELNSE RFKKFWEQAV KDLVNFGITK HEHTWSIKVN RFACYLYDAI
     YLYARALNEL IEETSEQQAH GYDPTRDGAA IIRKILNRKY SSMQGFDMRI NANGDAKGNY
     TLLAWQKVEP VRTKDDGNYY PLDHALDITA MFVDEGDGQN NMPKLVFHKP IIWLDGPTRD
     QPYCGFHGEL CRDYGGYISV ISFMLFAVVL IGGAISAGFI YRSRKFEKEL AMIWKIEVRE
     VQHLMEDNSS TISLFPDGND MVDHPWYTGT DGEKKGSGLR GVAYYKGTLV VLKELTFSRK
     PRELTRQAKI EMRVMRQLTH PNINSFMGII LCPYSICIVR EFCAKGSLMD ILRNREFKLD
     HLYIASFVED LINGMVYLHD SELKVHGNLK STNCLITSRW ALQVADFGYH EIREGRTQKG
     DVYAFGIILH EIFTRQGPFQ IFAKNEVQIS EIVARVAGGT CTRPSLSCIE GQDYVTDTMR
     LCWSEYPENR PDFKNGIKHK LKPMFAGIYK RNIMDHMMVM MEKYQNQLED LVDERTAELR
     EEQKRSQHLL QRISVAQQLL DGQDVVPESF PSVTIYFSDI VGFTRISGES TPMQVVTFLN
     KLYTKFDRII QKYDVYKEIA LMALRLLRAV RNFKIPHRSS EQLMLRIGIH TGSCVAGVVG
     KTMPRYCLFG DTVNTASRME SNGERKRYLT LKIHCSQPTR DVLTTITGFV LEERGTLTIK
     GKGQMTTYWL LDAEGYEFSD DEDYEEEEPT LAPEIFPRNS TFRAMRGSGF GPFFFLTALF
     M
//