ID   A0A3P7JYP6_LITSI        Unreviewed;       941 AA.
AC   A0A3P7JYP6;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=SLC12A transporter C-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=NLS_LOCUS9344 {ECO:0000313|EMBL:VDM91506.1};
OS   Litomosoides sigmodontis (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Litomosoides.
OX   NCBI_TaxID=42156 {ECO:0000313|EMBL:VDM91506.1, ECO:0000313|Proteomes:UP000277928};
RN   [1] {ECO:0000313|EMBL:VDM91506.1, ECO:0000313|Proteomes:UP000277928}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; UYRX01001521; VDM91506.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3P7JYP6; -.
DR   STRING; 42156.A0A3P7JYP6; -.
DR   Proteomes; UP000277928; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 2.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR018491; SLC12_C.
DR   InterPro; IPR004842; SLC12A_fam.
DR   PANTHER; PTHR11827:SF73; KAZACHOC, ISOFORM G; 1.
DR   PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR   Pfam; PF00324; AA_permease; 1.
DR   Pfam; PF03522; SLC12; 3.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000277928};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        16..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        80..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        231..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        269..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        425..449
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          228..506
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   DOMAIN          519..631
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   DOMAIN          637..803
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   DOMAIN          817..941
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   REGION          814..834
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   941 AA;  104742 MW;  438123556D2AD420 CRC64;
     MISRNLGPEL GGAVGILFYL GTTVAASMYI TGAVEILILY LIPGAKIFDN IFNCFRVLGT
     GLLIILGLIV LAGVKVVNKF ALPAVLVVLT CILCTFIGAF LKFHGSDSLK FCMVGDRPVD
     LVSFLEQYKY VPNCTATGLE PLFCEMKNNS MSCDAYYMHV AKVQNWMESG QPAIREEKAI
     PGIASGVFFD NLWSKYLQPH DILTKGKSSY EKSDQNNDEG TYIYVDQATS FMILIGVFFP
     SATGIMAGSN RSGNLKDASR SIPIGTLGAQ VTTTIVYLSG VVLFGSSISE MFIRDKFGQS
     AMSKLAIAEL AVPHPTVILI GCFLSTVGAG MQSLTGAPRL LQAIASDDVI PFLSRFQRLD
     SRGEPLRAIF LTLLICECGI LIAVIENITA LITQFFLMCY LGVNTACALQ SILRAPGWRP
     LFRYFHWSLS LLGSVLCVAV MFISAWHYAI VAIFIGIAVY KYIEYAGAEK EWGDGLRGLK
     LSAARFALLN LENRPQHTKN WRPQLLVIAP DSKECENGLF AFVSQLKAGK GLTLIAKCIE
     GNFIKHADAV EIARNEMDQQ IKSHKIHGFY DILMVNNIIE GIYCLVQTSG LGGLRHNTVV
     VVWPDEWAAS HEITVCQRFV STLRAADAAD CAILVPKNVK VFPSSQVKLH GYLDVWWIVH
     DGGLLMLLPF LLKQNKTWRN TRLRLFTIAQ MDDNTFNMKK DLETFLYHLR IEAQVFVIEL
     PDSDVSEYTY ERTMKMEERV RLLKDMQVGE RKLDVQSAVV EAARERKLSR ISDDDQLLHV
     KSEKTTEASE TIMEESELSE VVIRDRSEQS SRVHFSEDDI TISKNSRDDA GGESVKKYDN
     ELLSPATLVA DGKTNNIIMK NECFNVMRKN FNVRKMHTAV KLNELMREKS PDAQLVIVNL
     PGPPDLGSGE YYMEFIEALT EGLQRILLVR GTGTEVVTIY S
//